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Local anesthetics
Drug produce reversible conductionblock of neural impulses transmissionof autonomic, sensory and motor neural impulses
History
•The natives of Peru have chewed theleaves of the indigenous plant“Erythroxylon coca” the source of cocaine,to induce a feeling of well-being•Koller used cocaine for the eye in 1884•Halsted used cocaine as nerve block•First synthetic local-- procaine in 1905•Lidocaine synthesized in 1943
Local anestheticEsters
CocaineProcaineTetracaine
Amides
LidocaineBupivacainePrilocaine
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