The global market for advanced drug del
ivery systems was more than € 37.9 billion in 2000 and isestimated to grow and cross € 95 B (i.e., controlled release €19.8B, needle
less injection € 0.8B,
/impantable polymer systems €5.4B, transdermal € 9.6B, transnasal €12.0B, pulmonary €
7.0B, transmucosal €4.9B, rectal €0.9B, liposomal drug delivery € 2.5B, cell/gene therapy € 3.8B, and
balance covered by miscellaneous ).Table 1, mentions a brief list of representative peptide and proteindrugs and their potential functions and biomedical applications.Table 1 : List of representative peptide / protein drugs in bio-medical applications.#
Peptide / Protein drugs Functions / applications
1 Cardiovascular - active peptides & proteins-- Angiotensin II antagonist- Antriopeptins- Bradykinin- Calcitonin gene related factor- Captopril- Tissue plasminogen activator- Urokinase, streptokinase- Albumin, Plasma proteins- Lowering blood pressure.- Regulating CVS function & electrolyte & Fluidbalance.- Improving peripheral circulation.- Vasodilator.- Heart failure arrangement.- Dissolution of blood clots.- Thrombolytic therapy.- Blood volume replacement.2 CNS active peptides & proteins-- Cholecystokin (CCK-8 or CCK 32)- Delta sleep inducing peptide (DSIP)- B-endorphin- Melanocyte inhibiting factor I- Melacyte - stimulating hormone- Neuropeptide Y- Nerve growth factor- Suppressing appetite.- Improving sleep that is disturbed.- Relieving pain.- Improving the mood of depressed Patients.- Improving attention span.- Controlling feeding & drinking behavior.- Stimulating nerve growth & repair.3 GI active peptides & proteins-- Gastrin antagonist.- Neurotensin- Pancreatic enzymes- Somatostatin- Reducing secretion of gastric acid.- Inhibiting secretion of gastric juice.- Digestive supplement.- Reducing bleeding of gastric ulcers.4 Immuno modulating peptide & proteins-- Bursin- Colony stimulating factor- Cyclosporine- Enkephalins- Interferon- Selective B-cell differentiating hormone.- Stimulating granulocyte differentiation.- Inhibiting functions of Flymphocytes.- Stimulating lymphocyte blastogeneis.- Enhancing activity of killer cells.