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Drug Study

Drug Study

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Published by rhon_123rd
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Published by: rhon_123rd on Feb 17, 2010
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04/01/2013

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Drug name:Action: Indication:Contra-indicationAdverse reaction:NursingInterventionStreptomycinBinds to 30Sribosomal subunit, inhibitingproteinsynthesis inbacterial cell,which causesmis reading of genetic cosdand ultimatelycell deathe.
Intramuscular 
Tuberculosis
 Adult:
15mg/kgdaily; max:1 g daily.Reducemax dailydose to500-750mg inpatients>40 yr. Aspart of anintermittent therapy:25-30mg/kg/day2-3times/wk;max: 1.5g/dose.Not >120g over thecourse of treatmentshould begivenPregnancy,hypersensitivityGiddiness, vertigo,tinnitus, ataxia,hypersensitivityreactions,ototoxicity andnephrotoxicity.
Potentially Fatal:
Anaphylactic shock,aplastic anaemiaand agranulocytosis.Stevens-Johnsonsyndrome and toxicepidermalnecrolysis.
Draw bloodfor peak level1 hour I.Minjection.
Monitor liverand kidneyfunctiontests, watchfor evidenceof hepatotoxicity andnephrotoxicity
Monitortemp. stayalert forfever andother s/s of superinfection
Assessneurologicstatus andsensoryfunctioncarefullywatch closelyforneurotoxixity
 
unlessthere areno othertreatmentoptions.
Child:
20–40 mg/kg(max: 1 g)daily or25–30mg/kg(max: 1.5g) 2–3timeswkly.
Elderly:
≥60 kg:Dosagereductionis required.
Renal impairment:
Modification in doseor dosingintervalmay berequired, seizures
Monitor CBC,watch forevidence of blooddyscrasias
 
Drug name:Action:Indication:Contra-indication:Adverse reaction:Nursingintervention: TetracyclineTo inhibitbacterial proteinsynthesis at levelor 30S and 50Sbacterialribosomes and toalter cytoplasmicmembrane of susceptibleorganisms. To reduce thedevelopment of drug-resistantbacteria andmaintain theeffectiveness of Sumycin ‘250’and Sumycin‘500’ Tablets(TetracyclineHydrochloride Tablets) andotherantibacterialdrugs, Sum- ycin‘250’ andSumycin ‘500’ Tablets(TetracyclinePregnancy,hypersensitivity
Gastrointestinal:
 anorexia,epigastricdistress,nausea,vomiting,diarrhea, bulkyloose stools,stomatitis,sorethroat,glossitis, black hairytongue,dysphagia,hoarseness,enterocolitis, andinflammatorylesions (withcandidalovergrowth) inthe anogenitalregion, includingproctitisandpruritus ani. Rare
Monitor fors/s of superinfectionandhypersensitivityreaction.
With long-term use,monitorCBC, liverfunctiontests, andbonegrowth
Assessneurologicstatus,stay alert

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