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PaTho Physiology of Tuberculosis

PaTho Physiology of Tuberculosis

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Published by: GAURAV on Feb 21, 2010
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05/21/2012

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Pathophysiology of Koch’s Disease(Tuberculosis)
Predisposing Factors:Precipitating Factors:
Age- Occupation (
e.g Health Workers
)
Immunosuppression- Repeated close contact w/ infectedpersons
o
Prolonged corticosteroid therapy- Indefinite substance abuse via IV
Systemic Infection:- recurrence of infection
o
Diabetes Mellitus
o
End-stage Renal Disease
o
HIV or AIDS infectionExposure or inhalation of infectedAerosol through droplet nuclei(exposure to infected clients by coughing,sneezing, talking) Tubercle bacilli invasion in the apices of theLungs or near the pleurae of the lower lobesBronchopneumonia develops in the lung tissue(Phagocytosed tubercle bacilli are ingested by macrophages)
bacterial cell wall binds with macrophages
arrest of a phagosome which results to bacilli replicationNecrotic Degeneration occurs(production of cavities filled with cheese-likemass of tubercle bacilli, dead WBCs, necrotic lung tissue)drainage of necrotic materials into thetracheobronchial tree(eruption of coughing, formation of lesions)
PRIMARY INFECTION
 
Lesions may calcify (Ghon’s Complex)and form scars and may healover a period of time Tubercle bacilli immunity develops
(2 to 6 weeks after infection)
(maintains in the body as long as livingbacilli remains in the body)Acquired immunity leads to further growthOf bacilli and development of 
ACTIVE INFECTIONSIGNS AND SYMPTOMS
Pulmonary Symptoms:General Symptoms:
Dyspnea- Fatigue
Non-productive or productive cough- anorexia
Hemoptysis (blood tinge sputum)- Weight loss
Chest pain that may be pleuritic or dull- low grade fever with chillsand
Chest tightness sweats (often at night)
Crackles may be present on auscultationWith Medical InterventionWithout Medical intervention

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