Non-Essential Amino Acids

Fig: Biosynthesis of amino acids

TRANSAMINATION
Amino Acid1 +α
α-Keto Acid2 Amino Acid2 +α
α-Keto Acid1

NH3+ O
-
O 2 CCH 2 CH 2 CHCO 2 - + R-CCO 2 -
Glutamate
Pyridoxal phosphate (PLP)-
Dependent Aminotransferase

O
-
NH2
O 2 CCH 2 CH 2 CCO 2 - +
R-CHCO 2 -
α-Ketoglutarate
Transaminations: Role of PLP
CO2 -

CHO H N CHCH2 CH2 CO2-

C
HO CH2 OPO3-2
HO CH2 OPO3-2

H3 C N
+ H3 C N
H +
NH3 + H2 O H
- -
O 2 CCH 2 CH 2 CHCO 2 Tautomerization

O CO2 -
-
O 2 CCH 2 CH 2 CCO 2 - N CCH2 CH2 CO2-
CH2 NH2 CH2
HO CH2 OPO3-2 HO CH2 OPO3-2

H3 C N H2 O H3 C
+ N
+
H H
OXIDATIVE DEAMINATION
GLUTAMINE SYNTHESIS
Fig: The urea cycle
KREB BICYCLE
Fig: Degradation of amino acids