Federal Register / Vol. 71, No.
94 / Tuesday, May 16, 2006 / Notices 28365
93.337, 93.393–93.396, 93.837–93.844,
93.846–93.878, 93.892, 93.893, National
Institutes of Health, HHS)
Dated: May 8, 2006.
Anna Snouffer,
Acting Director, Office of Federal Advisory
Committee Policy.
[FR Doc. 06–4565 Filed 5–15–06; 8:45 am]
BILLING CODE 4140–01–M
DEPARTMENT OF HEALTH AND
HUMAN SERVICES
National Institutes of Health
Center for Scientific Review; Notice of
Closed Meetings
Pursuant to section 10(d) of the
Federal Advisory Committee Act, as
amended (5 U.S.C. Appendix 2), notice
is hereby given of the following
meetings.
The meetings will be closed to the
public in accordance with the
provisions set forth in sections
552b(c)(4) and 552b(c)(6), Title 5 U.S.C.,
as amended. The grant applications and
the discussions could disclose
confidential trade secrets or commercial
property such as patentable material,
and personal information concerning
individuals associated with the grant
applications, the disclosure of which
would constitute a clearly unwarranted
invasion of personal privacy.
Name of Committee: Center for Scientific
Review Special Emphasis Panel, Insulin.
Date: May 30, 2006.
Time: 9 a.m. to 11:30 a.m.
Agenda: To review and evaluate grant
applications.
Place: National Institutes of Health, 6701
Rockledge Drive, Bethesda, MD 20892,
(Telephone Conference Call).
Contact Person: Abubakar A. Shaikh, PhD.,
DVM, Scientific Review, National Institutes
of Health, 6701 Rockledge Drive, Room 6168,
MSC 7892, Bethesda, MD 20892. (301) 435–
1042. shaikha@csr.nih.gov.
This notice is being published less than 15
days prior to the meeting due to the timing
limitations imposed by the review and
funding cycle.
Name of Committee: Integrative,
Functional and Cognitive Neuroscience
Integrated Review Group, Neurobiology of
Motivated Behavior Study Section.
Date: June 5–6, 2006.
Time: 8 a.m. to 5 p.m.
Agenda: To review and evaluate grant
applications.
Place: Hyatt Regency Bethesda, One
Bethesda Metro Center, 7400 Wisconsin
Avenue, Bethesda, MD 20814.
sroberts on PROD1PC70 with NOTICES
Contact Person: Gamil C. Debbas, PhD.,
Scientific Review Administrator, Center for
Scientific Review, National Institutes of
Health, 6701 Rockledge Drive, Room 5170,
MSC 7844, Bethesda, MD 20892. (301) 435–
1018. debbasg@csr.nih.gov.
VerDate Aug<31>2005 16:06 May 15, 2006 Jkt 208001
Name of Committee: Center for Scientific
Review Special Emphasis Panel, Cancer
Genetics.
Date: June 7, 2006.
Time: 10 a.m. to 12 p.m.
Agenda: To review and evaluate grant
applications.
Place: National Institutes of Health, 6701
Rockledge Drive, Bethesda, MD 20892.
(Telephone Conference Call).
Contact Person: Manzoor Zarger, MS, PhD.,
Scientific Review Administrator, Center for
Scientific Review, National Institutes of
Health, 6701 Rockledge Drive, Room 6208,
MSC 7804, Bethesda, MD 20892. (301) 435–
2477. zargerma@csr.nih.gov.
Name of Committee: Endocrinology,
Metabolism, Nutrition and Reproductive
Sciences Integrated Review Group, Celluar
Aspects of Diabetes and Obesity Study
Section.
Date: June 7–9, 2006.
Time: 7 p.m. to 5 p.m.
Agenda: To review and evaluate grant
applications.
Place: Doubletree Hotel Bethesda, 8120
Wisconsin Ave., Bethesda, MD 20814.
Contact Person: Ann A. Jerkins, PhD.,
Scientific Review Administrator, Center for
Scientific Review, National Institutes of
Health, 6701 Rockledge Drive, Room 6154,
MSC 7892, Bethesda, MD 20892. 301–435–
4514. jerkinsa@csr.nih.gov.
Name of Committee: Cell Biology
Integrated Review Group, Membrane Biology
and Protein Processing.
Date: June 8–9, 2006.
Time: 8 a.m. to 5 p.m.
Agenda: To review and evaluate grant
applications.
Place: Melrose Hotel, 2430 Pennsylvania
Ave., NW., Washington, DC 20037.
Contact Person: Marcia Steinberg, PhD.,
Scientific Review Administrator, Center for
Scientific Review, National Institutes of
Health, 6701 Rockledge Drive, Room 5130,
MSC 7840, Bethesda, MD 20892. 301–435–
1023. steinbem@csr.nih.gov.
Name of Committee: Center for Scientific
Review Special Emphasis Panel, Cancer
Biomarker and Therapeutics Member
Conflict.
Date: June 9, 2006.
Time: 9:30 a.m. to 11:30 a.m.
Agenda: To review and evaluate grant
applications.
Place: National Institutes of Health, 6701
Rockledge Drive, Bethesda, MD 20892
(Telephone Conference Call).
Contact Person: Hungyi Shau, PhD.,
Scientific Review Administrator, Center for
Scientific Review, National Institutes of
Health, 6701 Rockledge Drive, Room 6214,
MSC 7804, Bethesda, MD 20892. 301–435–
1720. shauhung@csr.nih.gov.
Name of Committee: Center for Scientific
Review Special Emphasis Panel,
Microbiology and Material Science Related
Oral and Dental Applications: A Small
Business Panel.
Date: June 9, 2006.
Time: 11 a.m. to 5 p.m.
Agenda: To review and evaluate grant
applications.
PO 00000 Frm 00070 Fmt 4703 Sfmt 4703 E:\FR\FM\16MYN1.SGM
Place: National Institutes of Health, 6701
Rockledge Drive, Bethesda, MD 20892
(Telephone Conference Call).
Contact Person: Tamizchelvi Thyagarajan,
PhD., Scientific Review Administrator,
Center for Scientific Review, National
Institutes of Health, 6701 Rockledge Drive,
Room 4016K, MSC 7814, Bethesda, MD
20892. 301–451–1327. tthyagar@csr.nih.gov.
Name of Committee: Musculoskeletal, Oral
and Skin Sciences Integrated Review Group,
Skeletal Biology Development and Disease
Study Section.
Date: June 9–11, 2006.
Time: 6 p.m. to 3 p.m.
Agenda: To review and evaluate grant
applications.
Place: The Benson, 309 Southwest
Boulevard, Portland, OR 97205.
Contact Person: Priscilla B. Chen, PhD.,
Scientific Review Administrator, Center for
Scientific Review, National Institutes of
Health, 6701 Rockledge Drive, Room 4104,
MSC 7814, Bethesda, MD 20892. (301) 435–
1787. chenp@csr.nih.gov.
Name of Committee: Renal and Urological
Studies Integrated Review Group, Cellular
and Molecular Biology of the Kidney Study
Section.
Date: June 12–13, 2006.
Time: 8 a.m. to 1 p.m.
Agenda: To review and evaluate grant
applications.
Place: Holiday Inn Select Bethesda, 8120
Wisconsin Ave., Bethesda, MD 20814.
Contact Person: Shirley Hilden, PhD.,
Scientific Review Administrator, Center for
Scientific Review, National Institutes of
Health, 6701 Rockledge Drive, Room 4218,
MSC 7814, Bethesda, MD 20892. (301) 435–
1198. hildens@csr.nih.gov.
Name of Committee: Musculoskeletal, Oral
and Skin Sciences Integrated Review Group,
Arthritis, Connective Tissue and Skin Study
Section.
Date: June 12–13, 2006.
Time: 8 a.m. to 3 p.m.
Agenda: To review and evaluate grant
applications.
Place: Hilton Silver Spring, 8727 Colesville
Road, Silver Spring, MD 20910.
Contact Person: Harold M. Davidson, PhD.,
Scientific Review Administration Center for
Scientific Review, Nationnal Institutes of
Health, 6701 Rockledge Drive, Room 4216,
MSC 7814, Bethesda, MD 20892. 301/435–
1776 davidsoh@csr.nih.gov.
Name of Committee: Center for Scientific
Review Special Emphasis Panel,
Cardiovascular Development and
Differentiation.
Date: June 13, 2006.
Time: 11 a.m. to 12 p.m.
Agenda: To review and evaluate grant
applications.
Place: Gaithersburg Marriott
Washingtonian Center, 9751 Washingtonian
Boulevard, Gaithersburg, MD 20878.
Contact Person: Rajiv Kumar, PhD,
Scientific Review Administrator, Center for
Scientific Review, National Institutes of
Health, 6701 Rockledge Drive, Room 4122,
MSC 7802, Bethesda, MD 20892. 301–435–
1212. kumarra@csr.nih.gov.
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 28366 Federal Register / Vol. 71, No. 94 / Tuesday, May 16, 2006 / Notices
Name of Committee: Center for Scientific
Review Special Emphasis Panel, Member
Conflicts: Alcohol and Toxicology.
Date: June 13, 2006.
Time: 1 p.m. to 2 p.m.
Agenda: To review and evaluate grant
applications.
Place: National Institutes of Health, 6701
Rockledge Drive, Bethesda, MD 20892,
(Telephone Conference Call).
Contact Person: Christine L. Melchior,
PhD, Scientific Review Adminrstrator, Center
for Scientific Review, National Institutes of
Health, 6701 Rockledge Drive, Room 5176,
MSC 7844, Bethesda, MD 20892. 301–435–
1713. melchioc@csr.nih.gov.
Name of Committee: Risk, Prevention and
Health Behavior Integrated Review Group,
Psychosocial Development, Risk and
Prevention Study Section.
Date: June 15–16, 2006.
Time: 8 a.m. to 5 p.m.
Agenda: To review and evaluate grant
applications.
Place: St. Gregory Hotel, 2033 M Street,
NW., Washington, DC 20036.
Contact Person: Victoria S. Levin, MSW,
Scientific Review Administrator, Center for
Scientific Review, National Institutes of
Health, 6701 Rockledge Drive, Room 3142,
MSC 7759, Bethesda, MD 20892 301–435–
0912. levin@csr.nih.gov.
Name of Committee: Biobehavioral and
Behavioral Processes Integrated Review
Group, Psychopathology and Developmental
Disabilities Study Section.
Date: June 15–16, 2006.
Time: 8 a.m. to 5 p.m.
Agenda: To review and evaluate grant
applications.
Place: Marriott Wardman Park Washington
DC Hotel, 2660 Woodley Road, NW.,
Washington, DC 20008.
Contact Person: Jane A. Doussard-
Roosevelt, PhD., Scientific Review
Administrator, Center for Scientific Review,
National Institutes of Health, 6701 Rockledge
Drive, Room 3184, MSC 7848, Bethesda, MD
20892. (301) 435–4445. doussarj@csr.nih.gov.
Name of Committee: Brain Disorders and
Clinical Neuroscience Integrated Review
Group, Clinical Neuroimmunology and Brain
Tumors Study Section.
Date: June 15–16, 2006.
Time: 8:30 a.m. to 5 p.m.
Agenda: To review and evaluate grant
applications.
Place: The Fairmont Washington, DC, 2401
M Street, NW., Washington, DC 20037.
Contact Person: Jay Joshi, PhD., Scientific
Review Administrator, Center for Scientific
Review, National Institutes of Health, 6701
Rockledge Drive, Room 5184, MSC 7846,
Bethesda, MD 20892. (301) 435–1184
joshij@csr.nih.gov.
Name of Committee: Health of the
Population Integrated Review Group, Nursing
Science: Children and Families Study
Section.
sroberts on PROD1PC70 with NOTICES
Date: June 15, 2006.
Time: 8:30 a.m. to 5 p.m.
Agenda: To review and evaluate grant
applications.
Place: Bethesda Marriott Suites 6711
Democracy Boulevard, Bethesda, MD 20817.
VerDate Aug<31>2005 16:06 May 15, 2006 Jkt 208001
Contact Person: Fungai F. Chanetsa, PhD.,
Scientific Review Administrator, Center for
Scientific Review, National Institutes of
Health, 6701 Rockledge Drive, Room 3028B,
MSC 7770, Bethesda, MD 20892. (301) 435–
1262. chanetsaf@csr.nih.
Name of Committee: Center for Scientific
Review Special Emphasis Panel, Biology of
RNA Interference.
Date: June 15–16, 2006.
Time: 7 p.m. to 5 p.m.
Agenda: To review and evaluate grant
applications.
Place: Marriott Bethesda, 5151 Pooks Hill
Road, Bethesda, MD 20814.
Contact Person: Steven J. Zullo, PhD.,
Scientific Review Administrator, Center for
Scientific Review, National Institutes of
Health, 6701 Rockledge Drive, Room 4192,
MSC 7849, Bethesda, MD 20892. (301) 435–
2810. zullost@csr.nih.gov.)
Name of Committee: Center for Scientific
Review Special Emphasis Pane, Small
Business: Respiratory Sciences.
Date: June 19, 2006.
Time: 8 a.m. to 4 p.m.
Agenda: To review and evaluate grant
applications.
Place: Hyatt Regency Bethesda, One
Bethesda Metro Center, 7400 Wisconsin
Avenue, Bethesda, MD 20814.
Contact Person: Mushtaq A. Khan, DVM,
PhD., Scientific Review Administrator,
Center for Scientific Review, National
Institutes of Health, 6701 Rockledge Drive,
Room 2176, MSC 7818, Bethesda, MD 20892.
301–435–1778. khanm@csr.nih.gov.
Name of Committee: Integrative,
Functional and Cognitive Neuroscience
Integrated Review Group, Somatosensory and
Chemosensory Systems Study Section.
Date: June 19–20, 2006.
Time: 8:30 a.m. to 3 p.m.
Agenda: To review and evaluate grant
applications.
Place: Churchill Hotel, 1914 Connecticut
Avenue, NW., Washington, DC 20009.
Contact Person: Daniel R. Kenshalo, PhD.,
Scientific Review Administrator, Center for
Scientific Review, National Institutes of
Health, 6701 Rockledge Drive, Room 5182,
MSC 7844, Bethesda, MD 20892, 301–435–
1255. kenshalod@csr.nih.gov.
Name of Committee: Center for Scientific
Review Special Emphasis Panel, Shared
Instrumentation Grant Program: Surface
Plasmon Resonance (SPR) Instruments.
Date: June 19, 2006.
Time: 8:30 a.m. to 4 p.m.
Agenda: To review and evaluate grant
applications.
Place: The River Inn, 924 25th Street,
Washington, DC 20037.
Contact Person: Stephen M. Nigida, PhD.,
Scientific Review Administrator, Center for
Scientific Review, National Institutes of
Health, 6701 Rockledge Drive, Room 4212,
MSC 7812, Bethesda, MD 20892. 301–435–
1222. nigidas@csr.nih.gov.
Name of Committee: Center for Scientific
Review Special Emphasis Panel,
Applications in Mechanisms of Emotion,
Stress and Health.
Date: June 19, 2006.
Time: 2 p.m. to 3 p.m.
PO 00000 Frm 00071 Fmt 4703 Sfmt 4703 E:\FR\FM\16MYN1.SGM
Agenda: To review and evaluate grant
applications.
Place: Melrose Hotel, 2430 Pennsylvania
Ave., Washington, DC 20037.
Contact Person: Jane A. Doussard-
Roosevelt, PhD., Scientific Review
Administrator, Center for Scientific Review,
National Institutes of Health, 6701 Rockledge
Drive, Room 3184, MSC 7848, Bethesda, MD
20892. (301) 435–4445. doussarj@csr.nih.gov.
Name of Committee: Musculoskeletal, Oral
and Skin Sciences Integrated Review Group,
Oral, Dental and Craniofacial Sciences Study
Section.
Date: June 20–21, 2006.
Time: 8:30 a.m. to 4 p.m.
Agenda: To review and evaluate grant
applications.
Place: The River Inn, 924 25th Street, NW.,
Washington, DC 20037.
Contact Person: J. Terrell Hoffeld, DDS,
PhD., Dental Officer, USPHS, Center for
Scientific Review, National Institutes of
Health, 6701 Rockledge Drive, Room 4116,
MSC 7816, Bethesda, MD 20892. 301–435–
1781. hoffeldt@csr.nih.gov.
Name of Committee: Immunology
Integrated Review Group, Cellular and
Molecular Immunology—A Study Section.
Date: June 20–21, 2006.
Time: 8:30 a.m. to 5 p.m.
Agenda: To review and evaluate grant
applications.
Place: The Watergate, 2650 Virginia
Avenue, NW., Washington, DC 20037.
Contact Person: Samuel C. Edwards, PhD.,
Scientific Review Administrator, Center for
Scientific Review, National Institutes of
Health, 6701 Rockledge Drive, Room 4200,
MSC 7812, Bethesda, MD 20892. (301) 435–
1152. edwardss@csr.nih.gov.
Name of Committee: Center for Scientific
Review Special Emphasis Panel, PAR–04–
023 Bioengineering Research Partnerships.
Date: June 21, 2006.
Time: 8 a.m. to 5 p.m.
Agenda: To review and evaluate grant
applications.
Place: Omni Shoreham Hotel, 2500 Calvert
Street, NW., Washington, DC 20008.
Contact Person: Ross D. Shonat, PhD.,
Scientific Review Administrator, Center for
Scientific Review, National Institutes of
Health, 6701 Rockledge Drive, Room 3022A,
MSC 7849, Bethesda, MD 20892. 301–435–
2786. shonatr@csr.nih.gov.
Name of Committee: Hematology
Integrated Review Group, Erythrocyte and
Leukocyte Biology Study Section.
Date: June 22, 2006.
Time: 8 a.m. to 6 p.m.
Agenda: To review and evaluate grant
applications and/or proposals.
Place: Omni Shoreham, 2500 Calvert
Street, NW., Washington, DC 20037.
Contact Person: Delia Tang, MD, Scientific
Review Administrator, Center for Scientific
Review, National Institutes of Health, 6701
Rockledge Drive, Room 4126, MSC 7802,
Bethesda, MD 20892. 301–435–2506.
tangd@csr.nih.gov.
Name of Committee: Brain Disorders and
Clinical Neuroscience Integrated Review
Group, Clinical Neuroplasticity and
Neurotransmitters Study Section.
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 Federal Register / Vol. 71, No. 94 / Tuesday, May 16, 2006 / Notices
Date: June 22–23, 2006.
Time: 8:30 a.m. to 5 p.m.
Agenda: To review and evaluate grant
applications.
Place: Melrose Hotel, 2430 Pennsylvania
Ave., NW., Washington, DC 20037.
Contact Person: Willaim C. Benzing, PhD.,
Scientific Review Administrator, Center for
Scientific Review, National Institutes of
Health, 6701 Rockledge Drive, Room 5206,
MSC 7846, Bethesda, MD 20892. (301) 435–
1254. benzingw@csr.nih.gov.
Name of Committee: Renal and Urological
Studies Integrated Review Group, Urologic
and Kidney Development and Genitourinary
Diseases Study Section.
Date: June 26–27, 2006.
Time: 8 a.m. to 11 a.m.
Agenda: To review and evaluate grant
applications.
Place: Double Tree Rockville, 1750
Rockville Pike, Rockville, MD 20852.
Contact Person: Aftab A. Ansari, PhD.,
Scientific Review Administrator, Center for
Scientific Review, National Institutes of
Health, 6701 Rockledge Drive, Room 4108,
MSC 7814, Bethesda, MD 20892. 301–594–
6376. ansaria@csr.nih.gov.
Name of Committee: Center for Scientific
Review Special Emphasis Panel, Small
Business: Digestive Sciences.
Date: June 26, 2006.
Time: 8 a.m. to 4 p.m.
Agenda: To review and evaluate grant
applications.
Place: Residence Inn Bethesda, 7335
Wisconsin Avenue, Bethesda, MD 20814.
Contact Person: Mushtaq A. Khan, DVM,
PhD., Scientific Review Administrator,
Center for Scientific Review, National
Institutes of Health, 6701 Rockledge Drive,
Room 2176, MSC 7818, Bethesda, MD 20892.
301–435–1778. khanm@csr.nih.gov.
Name of Committee: Center for Scientific
Review Special Emphasis Panel, SBMI—
Small Business Medical Imaging.
Date: June 26–27, 2006.
Time: 8 a.m. to 4 p.m.
Agenda: To review and evaluate grant
applications.
Place: Embassy Suites at the Chevy Chase
Pavillion, 4300 Military Road, NW.,
Washington, DC 20015.
Contact Person: Xiang-Ning Li, PhD., MD,
Scientific Review Administrator, Center for
Scientific Review, National Institutes of
Health, 6701 Rockledge Drive, Room 5112,
MSC 7854, Bethesda, MD 20892. 301–435–
1744. lixang@csr.nih.gov.
Name of Committee: Center for Scientific
Review Special Emphasis Panel, Archiving
for Surveys of the Elderly—SBIR/STTR.
Date: June 26, 2006.
Time: 8 a.m. to 5 p.m.
Agenda: To review and evaluate grant
applications.
Place: Bethesda Marriott, 5151 Pooks Hill
Road, Bethesda, MD 20814.
sroberts on PROD1PC70 with NOTICES
Contact Person: Alfonso R. Latoni, PhD.,
Scientific Review Administrator, Center for
Scientific Review, National Institutes of
Health, 6701 Rockledge Drive, Room 3022C,
MSC 7770, Bethesda, MD 20892. 301–435–
1735. latonia@csr.nih.gov.
VerDate Aug<31>2005 16:06 May 15, 2006 Jkt 208001
Name of Committee: Center for Scientific
Review Special Emphasis Panel, Meg and
Pulsed Devices.
Date: June 26, 2006.
Time: 2 p.m. to 4 p.m.
Agenda: To review and evaluate grant
applications.
Place: National Institutes of Health, 6701
Rockledge Drive, Bethesda, MD 20892
(Telephone Conference Call).
Contact Person: Lee Rosen, PhD., Scientific
Review Administrator, Center for Scientific
Review, National Institutes of Health, 6701
Rockledge Drive, Room 5116, MSC 7854,
Bethesda, MD 20892. (301) 435–1171.
rosenl@csr.nih.gov.
(Catalogue of Federal Domestic Assistance
Program Nos. 93.306, Comparative Medicine;
93.333, Clinical Research, 93.306, 93.333,
93.337, 93.393–93.396. 93.837–93.844,
93.846–93.878, 93.892, 93.893, National
Institutes of Health, HHS.)
Dated: May 10, 2006.
Anna Snouffer,
Acting Director, Office of Federal Advisory
Committee Policy.
[FR Doc. 06–4566 Filed 5–15–06; 8:45 am]
BILLING CODE 4140–01–M
DEPARTMENT OF HEALTH AND
HUMAN SERVICES
National Institutes of Health
Prospective Grant of Exclusive
License: The Development of C-6 and
C-8 Modified cAMP-Derivatives for the
Treatment of Cancer
AGENCY: National Institutes of Health,
Public Health Service, HHS.
ACTION: Notice.
SUMMARY: This is notice, in accordance
with 35 U.S.C. 209(c)(1) and 37 CFR
404.7(a)(1)(i), that the National
Institutes of Health (NIH), Department
of Health and Human Services (HHS), is
contemplating the grant of an exclusive
patent license to practice the inventions
embodied in U.S. Patent Application
No. 07/198,489 filed May 23, 1988,
entitled ‘‘Use of 8-Cl-cAMP as
Anticancer Drug’’ [HHS Reference No.
E–132–1988/0–US–01], PCT
Application filed May 19, 1989 [HHS
Reference No. E–132–1988/0–PCT–02],
U.S. Patent Application No. 07/896,452
filed June 4, 1992, entitled ‘‘Use of 8-Cl-
cAMP as Anticancer Drug’’ [HHS
Reference No. E–132–1988/0–US–04],
U.S. Patent 5,792,752 filed October 27,
1994 and issued August 11, 1998,
entitled ‘‘Use of 8-Cl-cAMP as
Anticancer Drug’’ [HHS Reference No.
E–132–1988/0–US–05], U.S. Patent
5,902,794 filed September 22, 1997 and
issued May 11, 1999, entitled ‘‘Use of 8-
Cl-cAMP as Anticancer Drug’’ [HHS
Reference No. E–132–1988/0–US–06]
PO 00000 Frm 00072 Fmt 4703 Sfmt 4703 E:\FR\FM\16MYN1.SGM
28367
and Canadian Patent Application No.
133572 filed May 19, 1989, entitled
‘‘Use of 8-Cl-cAMP as Anticancer Drug’’
[HHS Reference No. E–132–1988/0–CA–
03], to Kuhnil Pharm. Co. Ltd., which
has offices in Seoul, Republic of Korea.
The patent rights in these inventions
have been assigned and/or exclusively
licensed to the Government of the
United States of America.
The prospective exclusive license
territory may be worldwide, and the
field of use may be limited to the
treatment of cancer with 8–Cl–cAMP.
This notice replaces the Prospective
Grant notice published in the Federal
Register on Tuesday, May 9, 2006 (71
FR 26979).
DATES: Only written comments and/or
applications for a license which are
received by the NIH Office of
Technology Transfer on or before July
17, 2006 will be considered.
ADDRESSES: Requests for copies of the
patent application, inquiries, comments,
and other materials relating to the
contemplated exclusive license should
be directed to: David A. Lambertson,
PhD., Technology Licensing Specialist,
Office of Technology Transfer, National
Institutes of Health, 6011 Executive
Boulevard, Suite 325, Rockville, MD
20852–3804; Telephone: (301) 435–
4632; Facsimile: (301) 402–0220; E-mail:
lambertsond@od.nih.gov.
SUPPLEMENTARY INFORMATION: Cyclic
AMP (cAMP) is a natural biological
product with a number of regulatory
functions at physiological levels. At
higher than physiological
concentrations, cAMP has the ability to
inhibit the aberrant growth of malignant
cells. Because cAMP is a natural
product involved in normal biological
function, this inhibition occurs without
causing significant toxicity. However,
this is not a feasible method for treating
cancer in vivo because of potential
interference with the physiological role
of cAMP.
C-6 and C-8 modified cAMP
derivatives also inhibit the growth of
malignant cells. One such derivative, 8-
Cl-cAMP, has effectively decreased
tumor growth in vitro and in vivo.
Specifically, 8-Cl-cAMP showed the
ability to decrease tumor growth in
leukemia mouse models and xenografts
of human tumors. Because of the low
toxicity associated with 8-Cl-cAMP, this
compound has promise as an anti-
cancer agent, particularly with regard to
hematological malignancies.
The prospective exclusive license will
be royalty bearing and will comply with
the terms and conditions of 35 U.S.C.
209 and 37 CFR 404.7. The prospective
exclusive license may be granted unless
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