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The Effect of a Japanese Traditional Medicine, Hachimijiogan (Kampo), on Regulatory CD4+CD25+ T Cells in Mikulicz’s Disease

The Effect of a Japanese Traditional Medicine, Hachimijiogan (Kampo), on Regulatory CD4+CD25+ T Cells in Mikulicz’s Disease

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Hachimijiogan, a Japanese herbal formulation consisting of eight crude drugs (Table 1), was indicated for Jinkyo (asthenia of kidney function) in traditional Japanese medicine. Many attempts have been made to clarify Jinkyo from the viewpoint of modern Western medicine. In the 1960s, Chinese medical researchers demonstrated that the level of urinary 17-OHCS (a metabolite of corticosteroid) concentration was lowered in patients diagnosed with Jinkyo, and they concluded that Jinkyo was consistent with hypofunction of the adrenal cortex.1
Thus, hachimijiogan is said to be adapted to corticosteroid-dependent cases, for example, severe allergies and autoimmune diseases in which dosages of corticosteroid cannot be reduced. Several reports showed hachimijiogan successfully reduced dosages of systemic corticosteroid in patients with chronic asthma2,3 or nephrotic syndrome.4
Hachimijiogan, a Japanese herbal formulation consisting of eight crude drugs (Table 1), was indicated for Jinkyo (asthenia of kidney function) in traditional Japanese medicine. Many attempts have been made to clarify Jinkyo from the viewpoint of modern Western medicine. In the 1960s, Chinese medical researchers demonstrated that the level of urinary 17-OHCS (a metabolite of corticosteroid) concentration was lowered in patients diagnosed with Jinkyo, and they concluded that Jinkyo was consistent with hypofunction of the adrenal cortex.1
Thus, hachimijiogan is said to be adapted to corticosteroid-dependent cases, for example, severe allergies and autoimmune diseases in which dosages of corticosteroid cannot be reduced. Several reports showed hachimijiogan successfully reduced dosages of systemic corticosteroid in patients with chronic asthma2,3 or nephrotic syndrome.4

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Published by: InnoVision Health Media on Mar 16, 2010
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05/12/2014

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