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DRUG STUDY

DRUG STUDY

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Published by snowyfingers
Spironolactone & Acetazolamide.
Im sure this will help you :)
Spironolactone & Acetazolamide.
Im sure this will help you :)

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Published by: snowyfingers on Mar 20, 2010
Copyright:Attribution Non-commercial

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02/25/2015

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D R U G S T U D TRADE NAMEGENERICNAMEFREQUENCY /ROUTECLASSIFICATIONACTIONINDICATIONCONTRAINDICATIONADVERSEEFFECTSDRUG-DRUGINTERACTIONDRUG-FOODINTERACTIONNURSINGRESPONSIBILITIES
AldactoneSpironolactone100-200 mg/dayPO for edema;100-400mg/day POforhyperaldosteronism; 50-100 mg/dayPO forhypertension
Pediatric :
3.3 mg/kg/day PO100mg/day POb.i.d
Potassium-sparing
diureticMild diuretic thatacts on the distaltubule to inhibitsodium exchange forpotassium, resultingin increasedsecretion of sodiumand waterconservation of potassium. An
aldosteroneantagonist 
.Manifests a slightantihypertensiveeffect. Interfereswith synthesis of testosterone andmay increaseformation of estradiol fromestrogen thusleading to endocrineabnormalities.Primaryhyperaldosteronism, adjunctivetherapy in thetherapy in thetreatment of edemaassociated withCHF, nephriticsyndrome,hepatic cirrhosis,treatment of hypokalemia orprevention of hypokalemia inpatients at highrisk if hypokalemiaoccurs; essentialhypertension.Acute renalinsufficiency,progressive renalfailure,hyperkalemia, andanuria. Clientsreceiving potassiumsupplements,amiloride ortriamterene.Dizziness,headache,drowsiness, rash,cramping,diarrhea,hyperkalemia,hirsutism,gynecomastia,deepening of thevoice, irregularmenses.1. ACE inhibitors /
Significant hyperkalemia
2. Generalanesthetics /
 Additivehypotension
3. Oralanticoagulants /
Inhibited by Spironolactone
4. Antihypertensives/
Increasehypotensive effect of both agents,Decrease dosage,especially of ganglionic blockers,by one-half 5.
Captopril /
Increased risk of significant hyperkalemia
6. Digoxin /
Increasehalf-life of digoxinleading todecreased clearance.Spironolactone may decrease inotropiceffect of digoxin
7. Other diuretics /
Often given together due to potassium-sparing effects of Spironolactone;monitor closely for  possible severehyponatremia
8. Triamterene /
Possible hazardoushyperkalemia
9. Lithium /
Increased risk for lithium toxicity r/t 
Avoidpotassium-richfoods(hazardoushyperkalemia):Avocados,bananas,broccoli,cantaloupe,dried fruits,grapefruit, limabeans, nuts,navy beans,oranges,peaches,potatoes,prunes,rhubarb, Sankacoffee,sunflowerseeds, spinach,tomatoes,watermelon1. Take asdirected with asnack or mealsto minimize GIupset. Report if nausea, bloating,anorexia,vomiting ordiarrhea persist.2. Instruct clientnot todrive/operatemachinery untildrug effects arerealized; maycause drowsinessor uneasy gait.3. Report if deep,rapidrespirations,headaches ormental slowingoccurs; mayindicatehyperchloremicmetabolicacidosis.4. Remind clientthat intake of Spironolactonemay causebreast swellingand diminishedsex drive due toreduction of testosteronelevels.5. Since the dugis metabolized inliver, report jaundice, tremorsor mentalconfusion; maydevelop hepaticencephalopathy
 
decreased renalclearance
10. Norepinephrine /
Decreased NE effect 
11. Salicylates /
Large doses may decreaseSpironolactoneeffect 
with liverdisease.
D R U G S T U D TRADE NAMEGENERIC NAMEFREQUENC/ROUTECLASSIFICATIONACTIONINDICATIONCONTRAINDICATIONADVERSEEFFECTSDRUG-DRUGINTERACTIONNURSINGRESPONSIBILITIES

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