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ntificReviewofVaccineSafetyDatalinkInformationJune7-8,2000SimpsonwoodR

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atCenterNor

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ross,Georgia

Dr.Orens

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ein:MynameisWalterOrenstein.I'mDirectoroftheNation

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lImmunizationProgramatCDCandIwanttothankallofyouforcominghereandtakingtimeoutofyourverybusyschedulestospendthenextdayandahalfwithus.Notonlydowethankyoufortakingtimeout,butfortakingthetimeoutonsuchshortnotice,andalsopu

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tingupwithwhatIgatherthoseofuswhoaretowniesheredidn'trealize,butapparentlythebiggestmeetinginAtlantawhichhastaken_

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upallthehotelsp

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llofthecars,soIthinkmanyofyouhavehadtotaketaxishere.Weappreciateyouputtingupwiththis,butatleastwedidarrangetheweathernicelyandyoucanlookoutoccasionallyandseesomebeautifultrees.IthinkIamparticularlyimpressedwiththequ

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lityofexpertise.Wetru

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yh

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vebeen

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bletoget

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tveryshortnoticesome-ofthemostoutstandingleadersinmultiplefields.Thatwillbeimportantininterpretingthedata.Wewhoworkwithvaccinestakevaccinesafetyveryseriously.V

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ccinesaregenerallygiventohealthychildrenandIthinkthepublichas,deservedlyso,veryhighexpect

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onsforvaccines

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fetyaswell

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stheeffectivenessofvaccinationprograms.Thosewhodon'tknow,initialconcernswereraisedlastsummerthatmercury,asmethylmercuryinvaccines,mightexceedsafelevels.Asaresultoftheseconcerns,CDCundertook,incollaborationwithinvestigatorsintheVaccineSafetyDatalink,anefforttoevaluatewhether

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s.Analysistodateraisesomeconcernsofapossibledose-responseeffectofincreasinglevelsofmethylmercuryinvaccinesandcertainneurologicdiagnoses.Therefore,thepurposeofthismeetingistohaveacarefulscientificreviewofthedata.Thisisnotapolicymakingmeeting.Vaccinepolicymakingwilltakeplaceafterthisconsultationaspartofthe

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dvisoryCommitteeonImmunizationPractices,orACIPdeliberations.Forthosewhodon'tknow,vaccinepolicyforCDCisreallysetthroughtherecommendationsofthevA

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visoryCommitteeonImmunizationPractices,orthe

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CIP.Thus,thisisascientificreviewtoevaluatethequalityofthescientificdata.Ourgoalistoassureourpoliciesarebasedonthebestavailablescientificinformation.Thisiswhatiscalledanindividualsimultaneousconsultation.WhatthatmeansiseachconsultantwillbeaskedfortheiropinionpubliclyonquestionswhichRogerBernierwillbringupinafewmoments.Althoughitwillbeofinteresttoseeiftheindividualconsultantstendtoagreeonparticularissues,thereisnottheneedtoreachcompleteconsensus.Yourindividualopinionss

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ouldbeveryuseful

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theACIPas

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beratesafterwardsonpolicyoptionswithregardtomercuryinvaccines.Wehopeyouwillparticipateindiscussions,listentothecommentsofothersandformyourownopinionsduringthisdayandahalfmeeting.

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Again,wethank

y

ouv

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rymuchfo

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cominghereandw

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lookforward

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oaproducti

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econsul

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ation.In

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rdertostart,

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incemany

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n'tkn

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weachother,perhapsifwecouldgoaroundtheroomandintroduceeachother.LetmeaskmaybeJohn,ifyouwanttostart.Dr.Modlin:Certainly.IamJohnModlin.I'mChair

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ftheACIPandamemberofthefacultyatDartmouthMedicalSchool.Dr.Stehr-Green:I'mPaulStehr-Green.I'manEpidemiologistbytraining.IamanAssociateProfessorofEpidemiologyattheUniversityofWashingtonSchoolofPublicHealthandCommunityMedicinea

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dI'malsoaconsultingEpidemiologistfortheNorthwestPortland

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reaIndianHealthBoard.Dr.Stein:IamMartyStein.IamonthefacultyofPediatricsattheUniversityofCalifornia,SanDiegowhereIamaGeneralPediatricianaswellasBehavioralPediatricandIco-chairedtheAmericanAcademyofPediatricsrecentpracticeguidelineonthediagnosisandevaluationforADHD.Dr.Saari:FmTomSaari,ProfessorofPediatrics,UniversityofWisconsininMadisonandtheDivisionofInfectiousDiseasesinPediatrics.I'malsoonthe

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APCOIDandI'verepresentedliaisonrelationshipstoanumberofnational_,_

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organizations.Dr.Word:I'mBonnieWord,IamattheStateUniversityofNewYorkinStonyBrook.IamalsoamemberoftheACIP.Dr.Rennels:I'mPeggyRermels,apediatricinfectiousdiseasespecialistattheCenterofVaccineDevelopment,UniversityofMaryland.IamamemberoftheACIPandtheAAPCommitteeonInfectiousDiseases.

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