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Neoplazia1

Neoplazia1

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Published by Leonard D
Anatomie patologica
Anatomie patologica

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Published by: Leonard D on May 15, 2008
Copyright:Public Domain

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02/01/2013

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Gena P53\u2014pe CR17 e inactivata in multe
cancere

Gena APC \u2013e inactivata in polipoza
colica cu osteoame, fibromatoza,chisti
epidermali

Gena NF1\u2014e inactivata in
neurofibromatoza tip1
Gena NF2\u2014e inactivata in schwanom
acusic bilateral
Gena WT1\u2014e inactivata in tumora
Wilms renala
Gena vh1\u2014e inactivata in tumori renale
in sindromul Hippel-Lindau
Sunt gene reglatoare, autozomal dominante ce
impiedica diviziunea anormala

Pierderea heterozigotiei lor prin deletii sau
mutatii a genelor supresoare tumorale permite
celulei sa prolifereze

BRCA1
BRCA2
In forme familiale ale neoplasmului
Au un rol in patogenia formelor de cancer

ovarian

In general gena p53=cel mai frecvent
afectata: 80% din cancerele colice 30-
50%din cancerul pulmonar,de san.E
principalul defect in sindromul
multicancer Li-Fraumeni

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