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Total Synthesis of Fentanyl - YG Suh, KH Cho, DY Shin. Arch Pharm Res, 21(1), 70-72 (1998)

Total Synthesis of Fentanyl - YG Suh, KH Cho, DY Shin. Arch Pharm Res, 21(1), 70-72 (1998)

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TOTAL SYNTHESIS of FENTANYL

Authors: Young-Ger Suh, Kyung-Ho Cho and Dong-Yoon Shin

Arch. Pharm. Res. 21(1): 70-72 (1998)

Arch. Pharm. Res. Vol. 21, No. 1, pp. 70-72, 1998

Journal: Archives of Pharmaceutical Research, Arch Pharm Res, Arch. Pharm. Res.

volume 21, Issue 1, pages 70-72 (1998)

volume: 21
issue/number: 1
pages: 70-72
Year: 1998

Received: November 15, 1997

ABSTRACT:
Fentanyl, a potent anilidopiperidine analgesic, has been synthesized from a simple phenethylamine by a four step sequence. The key part of this synthesis involves an efficient construction of phenylethylpiperidone skeleton via aminomethano desilyation-cyclization followed by Swern oxidation.

KEYWORDS:
Fentanyl, Analgesics, Piperidine, Piperidone, 4-Anilidopiperidine, 4-Anilinopiperidine, Anilinopiperidine, Anilidopiperidine, Aminomethano Desilyation Cyclization, opioid, sufentanil, carfentnail, lofentanil, acetylfentanyl, 3-methylfentanyl, 3MF, TMF, AMF, alphamethylfentanyl, Ohmefentanyl, beta-hydroxy, alpha-methyl, Mefentanyl, 4-methoxymethylcarbonyl, 4-methoxycarbonyl, 4-substituted piperidines, 4,4-disubstituted piperidines, 4-piperidines, 4-substituted fentanyl, 4,4-disubstituted fentanyl, fentanil, phentanyl, phentanil, N-phenylethyl-4-piperidone, N-phenethyl-4-piperidone, piperid-4-one, piperidinone, N-phenethyl-4-piperidinone, N-phenylethyl-4-piperidinone, piperidin-4-one, NPP, ANPP, fentanyl synthesis, opioid synthesis, opiate, mu opioid receptor, MOR, u opioid receptor, u receptor, mu receptor, mu, opioid analgesic, Sigfreid, Sigfried fentanyl synthesis, opiate alkaloid, poppy alkaloid, heroin, methadone, buprenorphine, subutex, suboxone, Swern Oxidation, drug synthesis, controlled substance, 4-propionanilidopiperidine, morphine, morphine-like analgesics, Paul Janssen, PAJ Janssen, Paul AJ Janssen, P. Janssen, P.A.J. Janssen, Janssen, Janssen Pharmaceuticals, Janssen Pharmaceutica, Belgian, Belgium, 4-phenylpiperidines, piperidones, piperidine, morpholine, organic chemistry, organic synthesis, novel organic synthesis, novel analgesic agent, novel analgetic, analgesic, analgetic, synthesis of fentanyl, fentanyl syntheses, review of fentanyl chemistry, fentanyl chemistry, 4-anilinopiperidine chemistry, 4-propionanilinopiperidine chemistry, 4-anilidopiperidine chemistry, 4-propionanilidopiperidine chemistry, piperidine chemistry, nitrogen chemistry, heterocyclic nitrogen compounds, organic compounds, opioid chemistry, opioid synthesis, fentanyl syntheses, structural analogues, analogs, fentanyl analog, fentanyl analogues, fentanyl analogs, N-arylalkylpiperidines, N-arylalkylpiperidine analgesics, N-arylalkylpiperidine opioids, N-arylalkylpiperidine opiates, N-arylalkylpiperidine chemistry, N-arylalkylpiperidine synthesis, 4-phenylpiperidine chemistry, 4-phenylpiperidine synthesis
TOTAL SYNTHESIS of FENTANYL

Authors: Young-Ger Suh, Kyung-Ho Cho and Dong-Yoon Shin

Arch. Pharm. Res. 21(1): 70-72 (1998)

Arch. Pharm. Res. Vol. 21, No. 1, pp. 70-72, 1998

Journal: Archives of Pharmaceutical Research, Arch Pharm Res, Arch. Pharm. Res.

volume 21, Issue 1, pages 70-72 (1998)

volume: 21
issue/number: 1
pages: 70-72
Year: 1998

Received: November 15, 1997

ABSTRACT:
Fentanyl, a potent anilidopiperidine analgesic, has been synthesized from a simple phenethylamine by a four step sequence. The key part of this synthesis involves an efficient construction of phenylethylpiperidone skeleton via aminomethano desilyation-cyclization followed by Swern oxidation.

KEYWORDS:
Fentanyl, Analgesics, Piperidine, Piperidone, 4-Anilidopiperidine, 4-Anilinopiperidine, Anilinopiperidine, Anilidopiperidine, Aminomethano Desilyation Cyclization, opioid, sufentanil, carfentnail, lofentanil, acetylfentanyl, 3-methylfentanyl, 3MF, TMF, AMF, alphamethylfentanyl, Ohmefentanyl, beta-hydroxy, alpha-methyl, Mefentanyl, 4-methoxymethylcarbonyl, 4-methoxycarbonyl, 4-substituted piperidines, 4,4-disubstituted piperidines, 4-piperidines, 4-substituted fentanyl, 4,4-disubstituted fentanyl, fentanil, phentanyl, phentanil, N-phenylethyl-4-piperidone, N-phenethyl-4-piperidone, piperid-4-one, piperidinone, N-phenethyl-4-piperidinone, N-phenylethyl-4-piperidinone, piperidin-4-one, NPP, ANPP, fentanyl synthesis, opioid synthesis, opiate, mu opioid receptor, MOR, u opioid receptor, u receptor, mu receptor, mu, opioid analgesic, Sigfreid, Sigfried fentanyl synthesis, opiate alkaloid, poppy alkaloid, heroin, methadone, buprenorphine, subutex, suboxone, Swern Oxidation, drug synthesis, controlled substance, 4-propionanilidopiperidine, morphine, morphine-like analgesics, Paul Janssen, PAJ Janssen, Paul AJ Janssen, P. Janssen, P.A.J. Janssen, Janssen, Janssen Pharmaceuticals, Janssen Pharmaceutica, Belgian, Belgium, 4-phenylpiperidines, piperidones, piperidine, morpholine, organic chemistry, organic synthesis, novel organic synthesis, novel analgesic agent, novel analgetic, analgesic, analgetic, synthesis of fentanyl, fentanyl syntheses, review of fentanyl chemistry, fentanyl chemistry, 4-anilinopiperidine chemistry, 4-propionanilinopiperidine chemistry, 4-anilidopiperidine chemistry, 4-propionanilidopiperidine chemistry, piperidine chemistry, nitrogen chemistry, heterocyclic nitrogen compounds, organic compounds, opioid chemistry, opioid synthesis, fentanyl syntheses, structural analogues, analogs, fentanyl analog, fentanyl analogues, fentanyl analogs, N-arylalkylpiperidines, N-arylalkylpiperidine analgesics, N-arylalkylpiperidine opioids, N-arylalkylpiperidine opiates, N-arylalkylpiperidine chemistry, N-arylalkylpiperidine synthesis, 4-phenylpiperidine chemistry, 4-phenylpiperidine synthesis

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Published by: jtjdp4 on Apr 24, 2010
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