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Korelasi Antara Kadar Iga Saliva Dengan Laju Aliran Saliva Pada Pasien Hiv Aids

Korelasi Antara Kadar Iga Saliva Dengan Laju Aliran Saliva Pada Pasien Hiv Aids

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Published by: dodol_cowboy on May 04, 2010
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12/06/2012

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KORELASI ANTARA KADAR IgA SALIVA DENGANLAJU ALIRAN SALIVA PADA PASIEN HIV/AIDS 
Oleh :Drg. IRNA SUFIAWATI, Sp.PMNIP. 132206501FAKULTAS KEDOKTERAN GIGIUNIVERSITAS PADJADJARANBANDUNG2008
 
ABSTRAKLatar belakang:
Kelainan kelenjar saliva merupakan salah satu manifestasi oral dariinfeksi HIV, yang dapat mempengaruhi kualitas dan kuantitas saliva yaitu komposisi dansekresi saliva. Sekresi antibodi, khususnya IgA saliva, merupakan indikator fungsi imunmukosa mulut yang berperan sebagai pertahanan utama terhadap patogen yangberkolonisasi dan menginvasi permukaan mukosa di dalam rongga mulut. Oleh karena itu, jika terjadi perubahan sistem imun ini, maka akan mempengaruhi integritas kesehatan gigidan mulut.
Tujuan:
Untuk mengetahui korelasi antara kadar IgA saliva dengan laju aliran saliva padapasien yang terinfeksi HIV di Rumah Sakit Cipto Mangunkusomo Jakarta.
Metode:
Penelitian ini merupakan penelitian observasional dengan desain potong lintang.Saliva keseluruhan dengan stimulasi paraffin-wax dikumpulkan dari 103 pasien HIV/AIDSdan 30 individu individu sehat. Saliva dikumpulkan dengan menggunakan metode
spitting
.Kadar IgA saliva ditentukan dengan metode imunoturbidimetri menggunakan alatturbitimer produk Behring.
Hasil
: Kadar IgA saliva adalah 141,55 ± 83,23 (kelompok HIV) dan 97,24 ± 38,25(individu sehat). Hasil uji Mann-Whitney U menunjukkan bahwa kadar IgA saliva padapasien HIV/AIDS tersebut lebih tinggi daripada nilai rujukan (p<0,1). Hasil Uji KorelasiSpearman menunjukkan hubungan yang bermakna antara kadar IgA saliva dengan lajualiran saliva (p < 0,0001 dan r = -0,552).
Kesimpulan
: Penelitian ini membuktikan terdapat korelasi yang kuat dan bermakna antarakadar IgA saliva dengan laju aliran saliva pada subyek HIV/AIDS.
Kata kunci
: IgA saliva, laju aliran saliva, HIV/AIDS.
 
 ABSTRACT  Background:
Salivary gland disesase id a common oral manifestation of HIV infection that can affect quality and quantity of saliva such as saliva composition and secretion. Antibodysecretion, especially salivary immunoglobulin A (IgA), is a useful indicator of mucosalimmune function. This immune system component is recognized as an important first-line of defense against pathogens which colonize and invade mucosal surfaces in the oral cavity.
Objectives:
The purpose of this study was to investigate salivary IgA levels and todetermine its correlation with salivary flow rates among HIV-infected Patients in Pokdisus AIDS Cipto Mangunkusomo Hospital
 
 Jakarta.
 Methods:
The design study was using a cross-sectional study. Whole paraffin-wax-stimulated saliva was collected from 103 HIV-infected patients and 30 healthy individuals.Saliva was collected using the spitting method. Salivary IgA levels were determined by theimmunoturbidimetry method using the Behring Turbitimer Analyser.
  Results :
 Salivary IgA levels were 141.55 ± 83.23 (HIV group) and 97.24 ± 38.25 (healthyindividuals). The Mann-Whitney U test showed salivary IgA levels were significantly higher in HIV/AIDS subjects compared with healthy individuals (p<0.1). Spearman's correlationtest between salivary IgA levels and salivary flow rates showed an inverse correlation (p <0,0001 and r = -0,552).
Conclusion:
This study indicates that total salivary IgA levels were significantly related tosalivary flow rates among HIV/AIDS subjects in Cipto Mangunkusumo Hospital .
 Key words:
Salivary IgA, salivary flow rates, HIV infection.
 

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