Endothelial cells also produce tissue plasminogen activator ,when fibrin is present in the endothelial system
Convert other protein from the liver called plasminogen into plasmin. Plasmin takes the fibrin strands
the fibrin willbreakdwown into fibrin degradation productsWhen healthy endothelial cells are injured:3 steps to stop the bleeding1.
early response to injury-
Nerve endings around the injured endothelium release vasoconstrictors ( called neurogenic reflexvasoconstriction)2.
Smooth muscels contraction ( reflex myogenic constriction)3.
When endothelial cells are injured, produced vasoconstrictors called endothelin
acts on the smooth musclesand constricts them (endothelial derived endothelin mechanism)Note: when endothelial cells are lost during injury , they lost the antiplatet and anticoagulatant properties which keepthe blood in liquid form(discussed above)-
Injured cells start producing chemical substances
stick on the exposed underline collagen
they havespecial hooks that hook up passing platelets
these chemical molecules also produces sticking glue thatsticks platelets over that area.( these chemical molecules are called von willebrand factor)Note: platelets have surface glycoprotein receptors (GP1 b)where von willebrand factor attachedThe process where platelets stick on the exposed collagen surface of endothelium is called platelet adhein.