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Parkinson disease is a debilitating neurodegenerative disorder characterized by the selective loss of nigrostriatal dopaminergic neurons and loss of DA in the striatum. Different groups of DA neurons in the ventral midbrain exhibit differences in susceptibility to degeneration during PD. The most susceptible DA neurons are theA9 group found in the ventral tier of the substantia nigra pars compacta.
\ue000 b rad y ki ne si a
\ue000 resting tremor
\ue000 abnormal postural reflexes
\ue000 Tremors in hands and fingers (pill-rolling) movements.
\ue000 Rigidity of muscles.
\ue000 Paucity of movement: short tottering steps, difficulty in getting started and in turning.
\ue000 Loss of balance.
\ue000 Handwriting becomes progressively smaller and gradually becomes illegible.
\ue000 Mask-like face of fixed expression; infrequent blinking.
\ue000 Excessive salivation.
\ue000 Speech is affected because patient cannot control muscles of speech; this may
2.Drug-induced Parkinsonism -A reversible form of Parkinsonism sometimes results from use of certain drugs - chlorpromazine and haloperidol, for example - prescribed for patients with psychiatric disorders. Some drugs used for stomach disorders (metoclopramide) and high blood pressure (reserpine) may also produce parkinsonian symptoms.
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