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AMINOGLYCOSIDES

AMINOGLYCOSIDES

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Published by Sunil
brief pharmacology of aminoglycosides for veterinary use
brief pharmacology of aminoglycosides for veterinary use

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Published by: Sunil on May 14, 2010
Copyright:Attribution Non-commercial

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12/21/2012

 
LKEBO@MUNO^EAD^
 ________________________________________________________________________________ Lkebo`muno~ead~ 'L@~% lyd l `yots oj blqtylm lba ~dke~ubqgdqen lbqeieoqen~ glzeb` somuil~en lkebo `yots~ mebhda `muno~eaenlmmu qo 9 oy koyd lkebo ~t`ly yd~eatd~" Qgd~d lbqeieoqen~lyd adyezda jyok ilnqdyel oj `dbe
^qydsqokund~
oy 
Kenyokobo~soyl
" L@ adyezda jyok `dbt~
^qydsqokund~
lyd blkda peqg ~tjjew „kuneb
8
' d`6 ~qydsqokuneb%
 
pgemd qgo~d adyezda jyok `dbt~
Kenyokobo~soyl
lyd blkda peqg ~tjjew „ keneb" 'd`6 `dbqlkeneb%
Nokkob syosdyqed~ oj lmm lkebo`mono~ead~
<" lmm lyd ilnqdyenealm lba koyd lnqezd lq lmhlmebd sG9"qgdu eobevd eb ~omtqeob8 lyd boq li~oyida oylmmu8 ae~qyeitqd obmu dwqylndmmtmlymu8 ao boq sdbdqylqd iyleb oy N^J>" lmm lyd dwnydqda tbnglb`da eb tyebd iu `mokdytmly jemqylqeob
1"
lmm lyd t~da l~ ~tmjlqd ~lmq~- pgeng lyd ge`gmu plqdy ~omtimd lba ~omtqeob~ ~qlimd joy kobqg~4"qgdu lnq iu ebqdyjdyeb` peqg ilnqdyelm syoqdeb ~ubqgd~e~:" lmm lyd syeklyemu lnqezd l`leb~q ldyoien `ylk bd`lqezd ilnemme- itq ~sdnqytk aejjdy~"
0"
qgdyd e~ obmu slyqelm nyo~~ yd~e~qlbnd lkob` qgdk8 lb oy`lbe~k yd~e~eqlbq qo obd L@ klu ~qemmyd~soba qo lboqgdy 
7"
ydmlqezdmu blyyop kly`eb oj ~ljdqu
5"
lmm dwgeieq oqoqowenequ lba bdsgyoqowenequ 8 bdokuneb lba jylkundqeb lyd L@ peqg ge`g~u~qdken qowenequ- qgdydjoyd t~da obmu qosenlmmu"
<3"
 
L so~q+lbqeieoqen djjdnq-
e"d"-
yd~eatlm ilnqdyenealm lnqezequ sdy~e~qeb` ljqdy qgd ~dytk nobndbqylqeobgl~ jlmmdb idmop qgd kebektk ebgeieqoyu nobndbqylqeob 'KEN%- lm~o e~ nglylnqdye~qen oj lkebo`muno~ead lbqeieoqen~8 qgd atylqeob oj qge~ djjdnq lm~o e~ nobndbqylqeob adsdbadbq" Qgd~d syosdyqed~ syoilimu lnnotbq joy qgd djjenlnu oj obnd+alemu ao~eb` yd`ekdb~ oj lkebo`muno~ead~"
Nml~~ejenlqeob6
<" Il~da ob oye`eb
+kuneb '
^qydsqokund~
%+
Lkebo`muno~ead~ adyezda jyok qgd `dbt~
^qydsqokund~
lyd blkda peqg qgd~tjjew „kuneb
D`~6
 
^qydsqokuneb- Bdokuneb -Jylkundqeb- Slyokokuneb- Yeio~qlkuneb- Hlblkuneb-Lkehlneb- Lyidhlneb-Idhlblkuneb- Aeidhlneb- Qoiylkuneb- Gu`yokuneb I- ^sdnqebokuneb- 
+keneb'
Kenyokobo~soyl
%+
qgo~d adyezda jyok qgd `dbt~
Kenyokobo~soyl
lyd blkda peqg qgd ~tjjew+keneb" D`~6
@dbqlkeneb-Bdqemkeneb-^e~okeneb-E~dslkeneb-Zdyalkeneb-L~qyokeneb
9" Il~da ob ~sdnqytk oj lnqezequ
Blyyop+~sdnqytk6
~qydsqokuneb lba aeguayo~qydsqokuneb- pgeng lyd klebmu lnqezd l`leb~qldyoien- `ylk+bd`lqezd ilnqdyel
 Dwslbada+~sdnqytk 
6 Bdokuneb- jylkundqeb 'bdokuneb I%- slyokokuneb 'lkebo~eaebd%- lbahlblkuneb glzd iyolady ~sdnqyl qglb ~qydsqokuneb qglq ojqdb ebnmtad ~dzdylm `ylk+so~eqezd l~ pdmml~ klbu `ylk+bd`lqezd ldyoien ilnqdyel" @dbqlkeneb- qoiylkuneb- lkehlneb- ~e~okeneb- lbabdqemkeneb lyd L@ peqg dwqdbada ~sdnqyl qglq ebnmtad
 S~dtaokobl~
 
ldyt`ebo~l
 Ngdke~qyu lba ^qytnqtyd 6
Qgd lkebo`muno~ead~ nob~e~q oj qpo oy koyd lkebo ~t`ly~ foebda eb`muno~eaen mebhl`d qo l gdwo~d btnmdt~- pgeng t~tlmmu e~ eb l ndbqylm so~eqeob" Qge~ gdwo~d- oy 
lkebonunmeqom
-e~ deqgdy ~qydsqeaebd 'jotba eb ~qydsqokuneb% oy 9+adowu~qydsqlkebd 'jotba eb lmm oqgdy lzlemlimdlkebo`muno~ead~%" Qgd~d noksotba~ qgt~ lyd '
lkebo`muno~eaen% lkebonunmeqom~
- lmqgot`g qgd ~eksmdy qdyk<
 
lkebo`muno~ead
e~ t~da nokkobmu qo ad~nyeid qgdk" L ydmlqda noksotba-
 ~sdnqebokuneb-
e~ lb lkebonunmeqomqglq aod~ boq nobqleb lkebo ~t`ly"
Qgd ngdkenlm ~qytnqtyd oj lsylkuneb aejjdy~ ~okdpglq jyok qglq oj qgd qusenlm lkebo`muno~ead~ itq e~ ~ekemly dbot`g qo id ebnmtada eb qge~ nml~~" Qgd ~qytnqtyd oj ~sdnqebokuneb e~ tbt~tlm- itq eq e~ jleymu nokslylimd qo oqgdy lkebonunmeqom~ peqg yd`lya qo eq~kdnglbe~k oj lnqeob lba lbqeilnqdyelm ~sdnqytk
Ngdkenlmmu- qgd lkebo`muno~ead lbqeieoqen~ lyd nglylnqdyevda iu lb
lkebonunmeqom  `yots
- peqg lkebo~t`ly~ lqqlngda qo qgd lkebonunmeqom yeb` eb `muno~eaen mebhl`d"
Idnlt~d oj keboy aejjdydbnd~ eb qgd so~eqeob oj ~ti~qeqtqeob~ ob qgd komdntmd~- qgdydklu id ~dzdylm joyk~ oj l ~eb`md lkebo`muno~ead"
Joy dwlksmd- `dbqlkeneb e~ l noksmdw oj `dbqlkeneb~ N
<
lba N
9
- lba bdokuneb e~ lkewqtyd oj bdokuneb~ I- N- lba jylaeokuneb"
Qgd lkebo `yots~ nobqyeitqd qo qgd il~en blqtyd oj qge~ nml~~ oj lbqeieoqen~- lba qgdguayowum `yots~ ob qgd ~t`ly koedqed~ qo ge`g l|tdot~ ~omtiemequ lba sooy mesea ~omtiemequ"
Ej qgd~d guayowum `yots~ lyd ydkozda 'd`- qoiylkuneb%- lbqeieoqen lnqezequ e~klyhdamu ebnydl~da"
Aejjdydbnd~ eb qgd ~ti~qeqtqeob~ ob qgd il~en yeb` ~qytnqtyd~ peqgeb qgd zlyeot~lkebo`muno~ead~ lnnotbq joy qgd ydmlqezdmu keboy aejjdydbnd~ eb lbqekenyoielm ~sdnqyl- slqqdyb~oj yd~e~qlbnd- lba qoweneqed~"
Lkebo`muno~ead~ lyd qusenlmmu |teqd ~qlimd" Pgdb qgd plqdy ~omtiemequ oj lblkebo`muno~ead e~ kly`eblm- eq e~ t~tlmmu qgd ~tmjlqd ~lmq qglq e~ t~da joy SO oy slydbqdylmlakebe~qylqeob
 
 
L so~q+lbqeieoqen djjdnq-
e"d"-
yd~eatlm ilnqdyenealm lnqezequ sdy~e~qeb` ljqdy qgd ~dytknobndbqylqeob gl~ jlmmdb idmop qgd kebektk ebgeieqoyu nobndbqylqeob 'KEN%- lm~o e~nglylnqdye~qen oj lkebo`muno~ead lbqeieoqen~8 qgd atylqeob oj qge~ djjdnq lm~o e~ nobndbqylqeobadsdbadbq" Qgd~d syosdyqed~ syoilimu lnnotbq joy qgd djjenlnu oj obnd+alemu ao~eb` yd`ekdb~oj lkebo`muno~ead~"
Kdnglbe~k oj Lnqeob6
Lkebo`muno~ead~ lyd koyd djjdnqezd l`leb~q ylseamu ktmqesmueb` oy`lbe~k~- lba qgduljjdnq lba tmqeklqdmu ad~qyou ilnqdyel iu ~dzdylm kdnglbe~k~"
Qgdey kleb ~eqd oj lnqeob e~ qgd kdkiylbd+l~~onelqda ilnqdyelm yeio~okd qgyot`g pgeng qgduebqdyjdyd peqg syoqdeb ~ubqgd~e~" Qo ydlng qgd yeio~okd- qgdu kt~q jey~q nyo~~ qgd ilnqdyelm ndmmplmm lba qgdb qgd ndmm kdkiylbd"
Qgd syeklyu ebqylndmmtmly ~eqd oj lnqeob oj qgd lkebo`muno~ead~ e~qgd >3^ yeio~oklm ~titbeq- pgeng nob~e~q~ oj 9< syoqdeb~ lba l ~eb`md <:^ komdntmd oj YBL" Lq mdl~qqgydd oj qgd~d yeio~oklm syoqdeb~- lba sdygls~ qgd <:^ yeio~oklm YBL l~ pdmm- nobqyeitqd qo qgd~qydsqokuneb+iebaeb` ~eqd- lba lmqdylqeob~ oj qgd~d komdntmd~ klyhdamu ljjdnq qgd iebaeb` lba~ti~d|tdbq lnqeob oj ~qydsqokuneb
Idnlt~d oj qgd somlyequ oj qgd~d noksotba~- l ~sdnelmevda qylb~soyq syond~~ e~ yd|teyda" Qgd jey~qnobndbqylqeob+adsdbadbq ~qds yd|teyd~ iebaeb` oj qgd lkebo`muno~ead qo lbeoben noksobdbq~eb qgd ndmm kdkiylbd" Qgd ~ti~d|tdbq ~qds~ lyd dbdy`u+adsdbadbq lba ebzomzd qgd qylb~soyq oj qgd somly- ge`gmu ngly`da lkebo`muno~ead lnyo~~ qgd nuqosml~ken kdkiylbd- jommopda iuebqdylnqeob peqg qgd yeio~okd~"
 
Qgd ayezeb` joynd joy qge~ qylb~jdy e~ syoilimu qgd kdkiylbd soqdbqelm" Qgd~d syond~~d~ lydktng koyd djjenedbq ej qgd dbdy`u t~da e~ ldyoienlmmu `dbdylqda
 
9
 
^dzdylm jdlqtyd~ oj qgd~d kdnglbe~k~ lyd oj nmebenlm ~e`bejenlbnd6
 
<% Qgd lbqeilnqdyelm lnqezequ oj qgd L@~ adsdba~ ob lb djjdnqezd nobndbqylqeob oj lbqeieoqenotq~ead qgd ndmm" 9% Lbldyoien ilnqdyel lba ebatnda ktqlbq~ lyd `dbdylmmu yd~e~qlbq idnlt~dqgdu mlnh lssyosyelqd qylb~soyq ~u~qdk~" >% Peqg mop owu`db qdb~eob- l~ eb gusowen qe~~td~-qylb~jdy ebqo ilnqdyel e~ aekebe~gda" 1% Aezlmdbq nlqeob~- d`- Nl lba K`- nlb ebqdyjdyd peqgqylb~soyq ebqo ilnqdyel idnlt~d qgdu nlb nokiebd peqg qgd ~sdnejen lbeoben ~eqd~ lba dwnmtadqgd nlqeoben lkebo`muno~ead~" 4% Qylb~soyq oj lkebo`muno~ead~ lnyo~~ ilnqdyelm ndmmkdkiylbd~ e~ jlnemeqlqda iu lb lmhlmebd sG8 l mop sG klu ebnydl~d kdkiylbd yd~e~qlbnd2<33+joma" :% Nglb`d~ eb o~komlyequ lm~o nlb lmqdy qgd tsqlhd oj lkebo`muno~ead~" 0% ^okdlkebo`muno~ead~ lyd qylb~soyqda koyd djjenedbqmu qglb oqgdy~- lba qgt~ qdba qo glzd `ydlqdy lbqeilnqdyelm lnqezequ"
Lbqeilnqdyelm ^sdnqytk
^qydsqokuneb lba aeguayo~qydsqokuneb glzd ydmlqezdmu blyyop ~sdnqyl- lba ilnqdyelm yd~e~qlbnd e~ idnokeb` sydzlmdbq" Gopdzdy- ~okd ~qlsgumononne lba l btkidy oj `ylk+bd`lqezd ilnemme lyd ~qemm~t~ndsqeimd- lkob` pgeng lyd ~qyleb~ oj 
 Lnqebokund~
 
ioze~
-
 Sl~qdtydmml
~ss -
 D 
 
nome
-
^lmkobdmml
~ss -
Nlksumoilnqdy 
 
 jdqt~
-
 Mdsqo~seyl
~ss - lba
 Iytndmml
~ss "
Kunoilnqdyetk
 
qtidyntmo~e~
e~ lm~o ~db~eqezdqo ~qydsqokuneb
 Bdokuneb- jylkundqeb- lba hlblkuneb glzd iyolady ~sdnqyl qglb ~qydsqokuneb- lba qgdey nmebenlm t~d e~ko~q ojqdb aeydnqda l`leb~q `ylk+bd`lqezd ~sdned~ ~tng l~
 D 
 
nome
lba
^lmkobdmml
-
 Hmdi~edmml
-
 Dbqdyoilnqdy 
-
 Syoqdt~
- lba
 Lnebdqoilnqdy 
~ss
Qgd lbqeilnqdyelm lnqezequ oj `dbqlkeneb- qoiylkuneb- hlblkuneb- bdqemkeneb- lba lkehlneb e~ aeydnqda syeklyemu l`leb~q ldyoien `ylk+bd`lqezd ilnemme" Qgd~d lkebo`muno~ead~ peqg iyolady ~sdnqyl qglqebnmtad
 S 
 
ldyt`ebo~l
lyd ojqdb ge`gmu djjdnqezd l`leb~q l pead zlyedqu oj ldyoien ilnqdyel" Lbldyoien ilnqdyel lba jtb`e lyd boq lssydnelimu ljjdnqda8 ~qydsqononne lyd t~tlmmu obmu koadylqdmu ~db~eqezd oy |teqd yd~e~qlbq
Hlblkuneb- mehd ~qydsqokuneb- gl~ l koyd mekeqda ~sdnqytk nokslyda peqg oqgdy lkebo`muno~ead~8 eb slyqentmly- eq ~gotma boq id t~da qo qydlq ebjdnqeob~ nlt~da iu
^dyylqel
oy 
 S" ldyt`ebo~l"
 
Lkebo`muno~ead~ glzd meqqmd lnqezequ l`leb~q lbldyoien kenyooy`lbe~k~ oy jlntmqlqezd ilnqdyeltbady lbldyoien nobaeqeob~
"
Qgdey lnqeob l`leb~q ko~q `ylk+so~eqezd ilnqdyel e~ mekeqda- lba qgdu ~gotma boq id t~da l~ ~eb`md l`dbq~qo qydlq ebjdnqeob~ nlt~da iu `ylk+so~eqezd ilnqdyel"
Eb nokieblqeob peqg l ndmm plmm+lnqezd l`dbq- ~tng l~ l sdbenemmeb oy zlbnokuneb- lb lkebo`muno~ead'~qydsqokuneb lba `dbqlkeneb glzd iddb qd~qda ko~q dwqdb~ezdmu% syoatnd~ l ~ubdy`e~qen ilnqdyenealmdjjdnq
eb zeqyo
l`leb~q dbqdyononne- ~qydsqononne- lba ~qlsgumononne"
Qgd ldyoien `ylk+bd`lqezd ilnemme zlyu eb qgdey ~t~ndsqeiemequ qo qgd lkebo`muno~ead~ Qoiylkuneb lba`dbqlkeneb dwgeieq ~ekemly lnqezequ l`leb~q ko~q `ylk+bd`lqezd ilnemme- lmqgot`g qoiylkuneb t~tlmmu e~koyd lnqezd l`leb~q
 S" ldyt`ebo~l
lba ~okd
 Syoqdt~
~ss"
Klbu `ylk+bd`lqezd ilnemme qglq lyd yd~e~qlbq qo `dbqlkeneb idnlt~d oj sml~kea+kdaelqda eblnqezlqeb`dbvukd~ lm~o pemm id yd~e~qlbq qo qoiylkuneb"
Lkehlneb lba- eb ~okd eb~qlbnd~- bdqemkeneb ydqleb qgdey lnqezequ l`leb~q `dbqlkeneb+yd~e~qlbq ~qyleb~ idnlt~d qgdu lyd l sooy ~ti~qylqd joy klbu oj qgd lkebo`muno~ead+eblnqezlqeb` dbvukd~"
L@ lyd nokkobmu t~da qo nobqyom monlm lba ~u~qdken ebjdnqeob~ nlt~da iu ~t~ndsqeimd ldyoien ilnqdyel'`dbdylmmu `ylk+bd`lqezd% idnlt~d oj qgdey djjdnqezdbd~~" Dwlksmd~ ebnmtad ~dsqendkel8qylngdoiyobngeqe~8 sbdtkobel8 o~qdolyqgyeqe~8 lba ebjdnqeob~ oj qgd tyeblyu qylnq- @E qylnq- lba ~heb lbapotba~" ^dzdylm lkebo`muno~ead~ lyd t~da qosenlmmu eb qgd dly~ lba dud~">

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