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BETA-OXIDACIÓN

BETA-OXIDACIÓN

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Published by Ivi
Bioquímica
Bioquímica

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Categories:Types, School Work
Published by: Ivi on May 14, 2010
Copyright:Attribution Non-commercial

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06/17/2013

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BETA-OXIDACIÓN
Pasos anteriores
β- oxidación
Modo en que se realiza el ciclo
Balance energético
 
Pasos anteriores: Activación de losácidos grasos
 Antes de la β- oxidación ocurre la activación de losácidos grasos a Acil- CoA que resulta de lacarnitina, que ocurre en el RE o en la membranamitocondrial externa.La enzima de esta reacción es la Acil CoA sintetasa
R–COOH + ATP + CoASH
Acil-CoA sintetasa
R–CO–SCoA + AMP + PP
i
+ H
2
O
 El ácido graso se une al coenzima A (CoASH),reacción que consume dos enlaces de alta energíadel ATP
 
Translocación de la matrizmitocondrial.
Luego se usa un transportador, la carnitina, paratraslocar las moléculas de acil-CoA al interiorde la matriz mitocondrial, ya que la membranamitoncondrial interna es impermeable a losacil-CoA.La carnitina se encarga de llevar los grupos aciloal interior de la matriz mitoncondrial pormedio del siguiente mecanismo.

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