This book provides
comprehensive and critical overview of the immunologi-cal aspects of autoimmune neurological disease, with particular emphasis onrecent research findings. Following introductory chapters on antigen recog-nition and self-non-self discrimination and on neuroimmunology, the chap-ters dealing with specific autoimmune neurological diseases are presented in astandardized format with sections on clinical features, genetics, neuropatho-logy, pathophysiology, immunology (including immunopathology, patho-genesis and immunoregulation) and therapy. Each chapter has a concludingsection, which summarizes the key points and suggests directions for futureresearch. The diseases range from relatively common conditions such asmultiple sclerosis, the Guillain-Barre syndrome and myasthenia gravis torarer conditions such as the stiff-man syndrome. Animal models of auto-immmune neurological disease are covered in detail, because of their import-ance in understanding the human diseases. The widely studied experimentalautoimmune encephalomyelitis
not only because it serves asa model for
disease of the nervous system, especially multiplesclerosis, but also because it is the prototype of
autoimmu-nity in general. This book is suitable for clinicians and neurologists managingpatients with autoimmune neurological disease, and for immunologists,neuroscientists and neurologists investigating the pathogenesis and patho-physiology of these disorders.