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Autoimmune Neurological

Autoimmune Neurological

Ratings: (0)|Views: 3,392|Likes:
Published by bodeadumitru9261
In organ-specific autoimmune disease, immune destruction is focused on a
limited range of tissues or cells, and the autoimmune response must persist
to produce disease
In organ-specific autoimmune disease, immune destruction is focused on a
limited range of tissues or cells, and the autoimmune response must persist
to produce disease

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Published by: bodeadumitru9261 on Jun 01, 2010
Copyright:Attribution Non-commercial

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05/15/2013

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This book provides
a
comprehensive and critical overview of the immunologi-cal aspects of autoimmune neurological disease, with particular emphasis onrecent research findings. Following introductory chapters on antigen recog-nition and self-non-self discrimination and on neuroimmunology, the chap-ters dealing with specific autoimmune neurological diseases are presented in astandardized format with sections on clinical features, genetics, neuropatho-logy, pathophysiology, immunology (including immunopathology, patho-genesis and immunoregulation) and therapy. Each chapter has a concludingsection, which summarizes the key points and suggests directions for futureresearch. The diseases range from relatively common conditions such asmultiple sclerosis, the Guillain-Barre syndrome and myasthenia gravis torarer conditions such as the stiff-man syndrome. Animal models of auto-immmune neurological disease are covered in detail, because of their import-ance in understanding the human diseases. The widely studied experimentalautoimmune encephalomyelitis
is
dealt with
 first,
 not only because it serves asa model for
T-cell-mediated
disease of the nervous system, especially multiplesclerosis, but also because it is the prototype of
T-cell-mediated
autoimmu-nity in general. This book is suitable for clinicians and neurologists managingpatients with autoimmune neurological disease, and for immunologists,neuroscientists and neurologists investigating the pathogenesis and patho-physiology of these disorders.
 
Autoimmune neurological disease

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