An t i b i o t i c s i nD en t i s t r y
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Antibiotics in Dentistry
Iyad Abou Rabii DDS, OMFS, MRes, PhD
ntibiotic is a a chemical substance derivable from a mold or bacterium that can killmicroorganisms and cure bacterial infections
Best use of Antibiotics
Use the right drug.2.
Use the right dose.3.
Use the correct dosing schedule.4.
Use a loading dose to rapidly achieve therapeutic blood levels.6.
Avoid combinations of bacteriostatic and bacteriocidal drugs.
Anaerobes? Consider if the infection is present > 3days or if no improvement
Know your enemy (bateria)
Identify your weapon
Specific for the pathogen.2.
Fewer disturbances of non-pathogenic bacteria.3.
Fewer side effects.4.
Rapid response for sensitive organisms. Ex: Pen VK, Pen G, Erythromycin5.
Affects both Gram + and Gram - bacteria, better for mixed infections.6.
May give up some effectiveness for Gram + to gain effectiveness for GramExamples: Amoxicillin, Ampicillin
Identify you patients
Age, allergies, compliance, pregnancy risk2.
Renal, hepatic, immunosuppresion, route applicability4.
Cost Brand name, length of course, alternatives?