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Gen Path 2007

Gen Path 2007

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Published by: vetpathforum on Jun 03, 2010
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05/19/2012

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Gen Path 2007 QuestionsK. Janardhan (P 124-130)January 15, 20071) The following contribute to antithrombotic properties of endothelium EXCEPTA) Intact endotheliumB) Prostacyclin and nitric oxide synthesisC) Expression of adenosine diphosphataseD) Interaction of thrombomodulin and thrombinE) Secretion of inhibitors of plasminogen activator 1) Answer: E; Page 126; intact endothelium, prostacyclin, nitric oxide and ADPase haveanti-platelet effect; Interaction of thrombomodulin with thrombin converts thrombin froma procoagulant molecule to anticoagulant molecule which activates protein C. Protein C,along with protein S, in turn cleaves factors Va and VIIIa . Inhibitor of plasminogenactivator prevents t-PA; thus inhibiting conversion of plasminogen to plasmin whichfurther prevents lysis of fibrin.K. JanardhanJanuary 29, 2008The stimulation of endothelial TLR4 by LPS in septic shock results inA) Decreased expression of tissue factor pathway inhibitor B) Decreased expression of thrombomodulinC) Cytokine productionD) All the aboveE) A and C2) The activation of the following is an important part of superantigen induced toxicshock syndromeA) EndotheliumB) MacrophageC) B-lymphocyteD) T-lymphocyteE) Dendritic cell3) The prognosis depends on the origin of shock; the following has better prognosisA) Hypovolemic shock B) Cardiogenic shock C) Septic shock D) None
 
E) All1) Answer: D; page 1402) Answer D; page 1403) Answer: A; page 143Gen PathBGC6/9/091. Which of the following is false regarding chemicals which are carcinogenic chemicalscausing
initiation
?a. They are non-lethal b. They are all direct actingc. The reactions are non-enzymaticd. They cause permanent DNA damagee. They attack DNA, RNA and proteinsAnswer:2. Which of the following are involved in the detoxification of polycyclic aromatichydrocarbons?a. Glutathione-S-transferase b. Glutathione peroxidasec. Superoxide dismutased. Cyt P450e. A and DAnswer:3. Initiated cells respond differently to promotors in which of the following ways?a. Less responsive to growth inhibitory signals b. Reduced growth factor requirementsc. More rapid cell divisionsd. Invasivenesse. A and BAnswer:4. Which of the following have been implicated as promoting agents?a. Viral infections b. Bile acidsc. Estrogen
 
d. Alcohole. all of the aboveAnswer:5. UVB radiation has been shown to cause mutations in which of the following tumor suppressor genes?a. P16/INK4a b. BRCA-1c. RASd. p53e. C and DAnswer:6. Epstein-Barr virus gains entry into lymphocytes by which of the following receptors?a. CD4 b. CD3c. CD 8d. CD21e. CD79 aAnswer:7. Which of the following causes hepatocellular carcinomas in woodchucks?a. Hepatitis virus b. Hepadnavirusc. Herpesvirusd. A and Be. A, B, and CAnswer:Answers:1. b p319-320 Robbins. Chemical carcinogens can be direct acting or non-direct acting(procarcinogens).

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