phytol and male and female mice fed 1% phytol exhibited midzonal hepatocellularnecrosis, periportalhepatocellular fatty vacuolation, and corresponding increases in liver levels of the phytol metabolites phytanic acid and pristanic acid. These results suggestthat phytol may cause selective
midzonal hepatocellular necrosis
in mice, an uncommon pattern of hepatotoxie injury, and that the greater suscept ibility of female mice may reflect a lower capacity tooxidize phytanic acid because of their intrinsically lower hepatie expression of sterol carrier protein-x(SCP-x) males have 5X.
Cardiac Valvular Pathology:
Comparative Pathology and Animal Models of Acquired Cardiac Valvular Disease.Mouse: Spontaneous valve disease has been described in the Swiss CD-i mouse. The alterationwas usually on the free edge of the leaf. The pulmonic valve was commonly affected. In the rat, theincidence was greatest in the mitral valve. In the Dog, The condition is referred to as myxomatousatrioventricular valvular degeneration, chronic valvular fibrosis, or endocardiosismost common in themitral valve, inflammation is rare, Hemorrhage and mineralization may be present, No valvular disease in populations of laboratory nonhuman primates has not been reported. rheumatic heart disease in rats isassociated with streptococcal M protein. Carcinoid heart disease occurs in most patients with carcinoidsyndrome, a metastatic neoplasm of serotonin-producing gastrointestinal endocrine cells, and ischaracterized by fibrous thickening of cardiac valves. [LDLr(-/-)ApoB(l00/l00)] develop aortic valvecalcification. Watanabe rabbits and diet-induced hypercholesterolemic and atheroscleroticmodels in wild-type rabbits. Valvular disease, primarily aortic valvular stenosis, has been described.
Evaluation of Subchronic Toxicity of Pet Food Contaminated with Melamine and Cyanuric Acid inRats:
food contained significant levels of cyanuric acid and melamine in a ratio of 1:6.8. Rats fed the dietof 50%–100% for three months exhibited elevated serum BUN and creatinine, as well as dose-dependentmelamine/cyanuric acid crystal-induced nephrotoxicity. In
conclusion, the combination ratio of cyanuricacid to melamine
and the acidic urine content were two factors that, upon repeated
exposure, determinedthe severity of the nephrotoxicity. Numerous MC crystals of various sizes were mixed with the necroticcell debris in both proximal and distal renal tubules. Slight
to severe inflammatory cell infiltration wasaccompanied by
renal tubular dilation and epithelial cell regeneration with
Dietary Fat–Influenced Development of Colon Neoplasia in Apc
Mice Exposed toBenzo(a)pyrene:
Consumption of well-done red meat and saturated fats
rich in polycyclic aromatichydrocarbons may be one of the causative
factors for sporadic colon cancer.
is a mutant mousewith multiple intestinal neoplasias. It has a mutated adenomatous polyposis coli (Apc), a tumor-suppressor gene, similar to that in patients with familial adenomatous polyposis. Apc
mouse mimics therapid development of adenomatous polyps that affect humans. Among the
several environmentaltoxicants, benzo(a)pyrene (B[a]P), a polycyclic
aromatic hydrocarbon (PAH) compound, has generatedthe most
interest, as this chemical is formed in red meat cooked at high
temperatures. Treatment consistedof 50 and
100 µg B(a)P/kg body weight dissolved in peanut or coconut
oil (representatives of unsaturatedand saturated fats, respectively. An increased
prevalence of adenomas in colons of mice that ingestedB(a)P
through saturated dietary fat compared to unsaturated fat and
The Metrial Gland in the Rat and Its Similarities to Granular Cell Tumors (
Tol Pat l
2009; 37; 474)Metrial glands are normal structures located in the mesometrial triangle of the pregnant rat uterus fromgestational day (GD) 8 through termination of pregnancy.
Metrial glands are composed of a dynamicmixed cell population of granulated metrial gland (GMG) cells, endometrial stromal cells,trophoblasts, blood vessels, and fibroblasts.
GMG cells are approximately 40 um in diameter and have