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Diuretics

Diuretics

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Published by GerardLum
Diuretics
Diuretics

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Published by: GerardLum on Jun 07, 2010
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01/25/2013

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DiureticsDefinitionDiuresis
Drug that↑ Rate of Bodily Urine Excretion 
Diuretics
↑ H2O Excretionfrom BodyAffect [Electrolytes], [Substances] in Body
AnatomyNephronGlomerulusTransports
 jslum.com|Medicine   
 
Renal Physiology, Diuretics Renin-Angiotensin-Aldosterone System (RAAS)FunctionsSegment Function H2O Permeability Transporter Diuretic with Major ActionGlomerulus
Glomerular Filtrate Extremely None None
Proximal Convulated Tubule
Reabsorb 65% (Na, K, Ca, Mg)Reabsorb 85% (NaHCO)Reabsorb 100% (Glucose, a.a.)Isoosmotic – Reabsorb H2OVery Na/H(NHE3)Carbonic AnhydraseCarbonic Anhydrase Inhibitors
Proximal Tubule(Straight Segment)
Secretion/ Reabsorption of Organic Acids/ BasesVery Acid, Base Transporters None
Thin Descending Loop Henle
Passive Reabsorption of H2O Aquaporins None
Thick Ascending Loop Henle
Active Reabsorption 15-25%(Na,K,Cl)Secondary ReabsorptionVery ↓Na/K/2Cl (NKCC2)Loop Diuretics
Distal Convulated Tubule
Active Reabsorption of 4-8%(of Filtered Na, Cl)Ca Absorbed - PTH controlVery ↓Na/Cl(NCC)Thiazides
Cortical Collecting Tubule
Na Reabsorption (2-5%)coupled to K, H SecretionADH ControlledNa Channels (ENaC) K ChannelH TransporterK Sparing Diuretics
Medullary Collecting Duct
H2O Reabsorption(ADH Controlled)↑ AquaporinsVasopressin Antagonist
 jslum.com|Medicine   

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