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AE mOILOb: haem ~Prothetic /eunctional group ~chrome /colovted PORPHYRIN "Ron PoRPH uRIN a ; ' Cyclic comPounds denivad from Rorphin nucleus 2 4 Pytele wings linked by 4-metheng! * bridges C-cH=) labelled «5 Bry.d S Truc QLOBIN, ©¢ isomer 0 Sah cS os ~*UPes of Porphyrin @__|| t ~ Bhoup subsitvied at 7 TO) symmeny bot assymmeiny at 2 ® t _ x | a fo e IRON ~ Present in Fentous cheat) Biocken, T Getrapyrole sings) Side@ chains aHached to Pytole tings @ Mm = methyl v e = ving! = propionyt ~ "mainly atached fo N toa many free atoms > Provent PeAPOVS ~ fervic = 2 GcNal bonds (covalent 1 | bonds) at 1 ®IV Pyrola sings Ss Zz ~ 2 non-covalent bonds [2 - Ee st T © tt pyroie ‘i an rings /~ ~ 2 Peron dicviah to beam plane, | u Sth N OF histigine 5 imidazole, Fing Core: G4, : Ofygenated : bound to Os deoxygenated : hot bound to Os imal histidine) Fe protein part / apopratein type op histone Csimpl® protein) ~axial ratio Jess than lo aoe ~ globuiab pretein — 3 8 Pret ~ qudterhary Sivaere , contain 4 PolypePtide chain with porphyrio. oN = globin’s polypeptides each hos pomest to aitach 6 &O + Questions ?? fatio heme + globin @ an © uy ® v4 @ an Answer: 4 +1 B-chain ~ Ffokmed of % &-helical siuctures sright handed ALARA ¥Protimal histidine / Histidine Fg & distal histidine /tistidine cy cobs oF ha in ~formed of 3% %-helical strectongs Proximal histidine q A Be DE FG distal histidine

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