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AFIP Summaries

AFIP Summaries

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Published by: vetpathforum on Jun 14, 2010
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03/16/2013

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ConferenceSlideSpeciesetiologyMorph Dxnotesnotes/DDX2008-20091.11Elephant sealToxoplasma gondiiCerebrum, brainstem:Meningoencpehalitis, necrotizing,histiocytic, multifocal mild withlymphoplasmacytic perivascularcuffing and few protozoal cystsinfects many cells includinglymphoid, resides in aparasitophorus vacuole whichprotects it from the hostresponsecysts have a thin outer wall containingnumerous bradyzoites1.22MacaqueOesophagostomumColon: Granulomas, multifocalwith few strongyloid nematodesCuticleHypodermisMusculatureDigestive tractReproductive tractRanges inthicknessimmediately internal tothe cuticleUnder the hypodermisMouth, buccal cavity,esophagus, intestine, andanusOnly females are present inRhabditoid infectionsAlae-winglikeextensionsextensions of thehypodermis into thepseudocoelom are calledlateral chordscoelomyarian/polymyarian: extendinto body cavity/ numerous/ talllining cells- multinulceate, oruninucleate, pigmented fromdigested blood or bileFemales have two tracts, Males haveonePlatymyarian/meromyarian:flattened against the hypodermisSome produce eggs others larvae1.33HorseNephroblastomaTriphasic- equal amounts of all 3cell lineagesBlastemal cells do not exhibitcytomorphologiccharacteristics ofmesenchymal or epithelialcells1.44PigActinobacillus suisLung: Pneumonia, necrotizing,histiocytic and neutrophilic withvasculitis, necrotic leukocytes (oatcells), fibrin and coccobacilliA suis can also cause rhoboidcutaneous infarctions similarto Erysipelas2.15MouseCorynebacterium bovisSkin: Hyperkeratosis,orthokeratotic, with epidermalhyperplasia and mild dermatitisAthymic nude mice and SCIDmiceacanthosis, kyperkeratosis andcoryneform bacteria in the stratumcorneum2.26MouseHistiocytic SarcomaLiver: Histiocytic SarcomaSprague Dawley Rats > 12months old; Liver, LN, Spleen,Mediastinum,Retroperitoneum, SQ; Ratshave nodular lesions, Micehave diffuse infiltrationsLiver, hepatocytes: Microvesicularlipidosis
 
2.37MacaqueCorynebacteriumulceransLung: Pleuropneumonia,fibrinonecrotic, diffuse, severe,with abundant coccobacilliSimilar to C diptheriae andpseudotuberculosis2.48African GreenMonkeyAutoimmune ThyroiditisThyroid gland: thyroiditis,lymphoplasmacytic, chronic, withfollicular hyperplasia and colloiddepletion3.19DogCanine Distemper andCanine Adenovirus type2Lung: Pneumonia,bronchointerstitial, necrotizing,multifocal to coalescing, withsyncytia and intranuclear andintracytoplasmic inclusions3.210CatFeline Systemic ReactiveAngioendotheliomatosisHeart: atypical endothelialproliferation(angioendotheliomatosis),multifocal with few fibrin thrombi,rare myocyte degeneration andnecrosis and minimallymphoplasmacytic myocarditisproliferating cells are positivefor SMA and VWF (endothelialcells and pericytes)3.311Rainbow troutRenibacteriumsalmoninariumKidney, posterior: Nephritis,necrotizing, granulomatous,severe, with myriad intrahistiocyticbacteria3.412CatFeline Ventral AbdominalAngiosarcomafibro-adipose tissue and skeletalmuscle: feline ventral abdominalangiosarcomaCd31 and VWF, and lymphaticVessel endothelial receptor-1are positive4.113HorseSeminomaTesticle, splenic capsule-seminomaRight testicle: hypoplasia,diffuse4.214catMyelolipomaLiver: Myelolipoma, multiplealso found in spleen, adrenaland spinal cord of dogs, andadrenal glands of cattle4.315RabbitEimeria steidaeLiver: Cholangiohepatitis,proliferative, lymphohistiocytic,chronic, multifocal, withintraepithelial coccidia4.416RatPituitary adenomaPituitary gland, pars distalis:AdenomaMost are prolactin secreting5.117swanHighly Pathogenic AvianInfluenza (H5N1)Cerebrum: Neuronal necrosis,multifocal with glial nodulesNecrotic and hemorrhagicchanges are centered onCNS, pancreas, lungs, liver,adrenals, heart, and lymphoidorgans5.218CatFrancisella tularensissplenitis, necrotizing, random,multifocal, moderate with lymphoiddepletion
 
5.319GoatCapripoxvirusHaired skin: dermatitis,proliferative, and necrotizing,subacute with intraepidermalvesicles, balooning degeneration,and ICIBvasculitis?Sheeppox, goatpox, and lumpyskindiseaseLung: Pneumonia,bronchointerstitial, proliferativewith intraepithelialintracytoplasmic ICIB5.420BisonMycoplasma bovisLung: Pneumonia, necrotizing,fibrinosuppurative, diffuse, withinterlobular edema and fibrosisAcute lesions begin in airwaysand progress to multifocal tocoalescing caseonecroticdebris often containingmineralGross: Well demarcated,caseonecrotic nodules up to a fewcentimeters in diameter disperseedthroughout the cranioventral lunglobes6.121DogAcute RespiratoryDistress syndromeLung: Pneumonia,bronchointerstitial,fibrinosuppurative, withbronchiolar and alveolar hyalinemembranes and bacteriaIntrabronchial administrationof Staph aureusHyaline membranes are homogenousgranular or fibrillar eosinophilicmaterial composed of necroticepithelial cell debris mixed with fibrinand plasma- Surfactant apolipoproteinA, VWF, and Cytokeratin AE1/AE3ddx: Oxygen toxicity, smoke,phosgene, mercury vapor,kerosene, paraquat, highaltitude, bleomycin, busulfan,methotrexate6.222Macaque (MALE)Ductular Carcinoma InsituMammary gland: ductularcarcinomaE cadherin is lost in lobulartumors (LCIS), so isdiagnostic for DCISSpeciesMammary ChangesCauseRatFibroadenoam (SD)ProlactinRabbitMammary DysplasiaPituitary tumor secreting prolactinMouseMammary hyperplasia(FVB/N)Pars distalis prolactinMouseMammary tumorMammary tumor viruses (MMTV)CatFibroepithelial hyperplasiaProgesterone administrationCanineGynecomastiaSertoli cell tumor6.323Mouse (Adult)RhabdomyosarcomaSkeletal muscle, hind limb:Rhabdomyosarcoma, embroyonalwith focal osteosarcomatousdifferentiationWhy diagnose embryonal if itsan adult mouse?Desmin, Myosin, Titin, Myogenin, andmYoD> Actin, Myoglobin, VimentinMyogenin and myoD areexpressed in the nucleus ofmyoblastsBMP is not expressed inrhabdomyosarcoma

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