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BioE Thesis Defense

BioE Thesis Defense

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Published by Josh
Bioengineering thesis defense, presentation
Bioengineering thesis defense, presentation

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Categories:Types, Research
Published by: Josh on Jun 24, 2010
Copyright:Attribution Non-commercial

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10/23/2010

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The Novel Design of a Bioreactor for
in vitro
Proliferation and Differentiationof Human MesenchymalStem Cells
 Author 
: Joshua Salvi, Department of Bioengineering
Honors Advisor 
: Dr. William Hancock, Bioengineering
Thesis Advisors
:Dr. Henry Donahue, Orthopaedics(HY)Dr. Peter Butler, Bioengineering (UP)
 April 16, 2009
 
A
l-Rubeai, et al., 2005; Davies, et al., 2006
Ba
ckgr
650,000
bone allograft transplantationsLow Risk of HIV infection 1:150,471Failure rate within ten years 
60%
SOLUTION? 
T
issue-engineered implants
 
H
yptss
Nanoscalesubstrates
select for subpopulations of progenitor cells throughdifferentiation into the osteoblasticlineage, as influenced by surface characteristics,including chemistry and topography.The same progenitor cell lines cultured on
three-dimensional calcium phosphatescaffolds
will display significantly maintained differentiation potential with continuedexpansion
in vitro
comparedwith two-dimensionalsubstrataand flat controls.
 
A bioreactor designed with
finite element methods
will satisfy all the criteria neededfor long-term culture on three-dimensionalscaffolds with inducedbiophysicalsignals.
2D Substrata3D ScaffoldsFEM as a
T
oolBioreactorDevelopment

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