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Primary Immunodeficiency

Primary Immunodeficiency

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Published by Aditya Pathak
oral manifestation of primary immunodeficiency
oral manifestation of primary immunodeficiency

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Published by: Aditya Pathak on Jul 02, 2010
Copyright:Attribution Non-commercial

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05/15/2012

 
Primary immunodeficiency
 
When part of the immune system is missing ordoes not work correctly, immunodeficiencyoccurs; it may be either congenital (primary) oracquired ( secondary).
Primary immunodeficiency diseases are aheterogeneous group of inherited disorders withdefects in one or more components of theimmune sstem.
Primary immunodeficiency diseases (PID) arehereditary disorders, caused by mutations of specific genes.
More than 150 different types of PID have beenreported to date.
 
CAUSES OF PRIMARY IMMUNODEFICIENCY
Mutations: rare, affect any part of the immunesystem and cause severe disease
Polymorphisms: very common traits, affectmoderate increased risk for infection
Polygenicdisorders: relatively common, affectmainly antibodies and cause severe disease

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