D’ADAMO

NAP PROFESSIONAL SERVICES

Tranquility Base™ (Theanine - GABA complex)

60 Veggiecaps per bottle.

Suggested retail price: 26.95
Occasional stress and anxiety are natural activity with both nicotinic and muscarinic binding properties.
functions of life, but when balanced with (8) Clinical research suggests that lemon balm induces a
appropriate amounts of relaxation, meditation, calming effect. (8)
and exercise, occasional stress can be taken
in stride and can actually support health and Chamomile (Matricaria recutita)
well-being. Sometimes, however, the scale • The active constituents of Chamomile include quercetin,
tips too far; patients may not get that daily apigenin, and coumarins, and the essential oils matricin,
relaxation time, and we can find a bit more of chamazulene, alpha bisaboloid, and bisaboloid oxides. (11)
an imbalance than we’re used to. Tranquility Although the constituent(s) responsible for the sedative
Base™ is designed for times like these to help provide mental activity of German chamomile are unclear, some preliminary
and physical relaxation, while decreasing occasional stress and research suggests that apigenin can bind to gamma-
anxiety. Only the best researched herbs have been included. aminobutyric acid (GABA) receptors.
• GABA receptors are the primary receptor sites of
Product History benzodiazepines in the central nervous system. However,
This product was introduced by NAP in 2004 after first being other research suggests that apigenin doesn’t affect GABA
specifically designed for use in The D’Adamo Clinic. receptors, and other constituents of German chamomile are
responsible for the sedative activity. (12,13).
Description/Background
Tranquility Base comprises four synergistic ingredients. Actions and Indications
GABA (Gamma-Aminobutyric Acid) • Diminishes symptoms of PMS
• GABA in the central nervous system, is the primary • Improves learning performance
inhibitory neurotransmitter. It is synthesized in the brain by • Heightens mental acuity – neurotransmitter
the decarboxylation of glutamate. (1,2)
• Promotes concentration
• GABA exerts anticonvulsant, sedative, and anxiolytic effects
• Acts antagonistically against the paralysis induced by caffeine
at the cellular level. (1,2)
• Supports the immune system
L-Theanine
• Lowers blood pressure
• L- Theanine is the major amino acid found in green tea (3,4)
• Increases formation of the inhibitory neurotransmitter GABA
and appears to be a relaxant that increases alpha-waves,
producing mental and physical relaxation while decreasing • Increases brain dopamine levels among other positive benefits
stress and anxiety, without inducing drowsiness. (5) with no known downside.
• Theanine has historically been used for its relaxing and anti- Directions
anxiety effects. It’s thought that theanine might work for
1 capsule 1-2 times daily, or as directed by physician.
anxiety by increasing levels of GABA and serotonin. (6)
Lemon balm (Melissa officinalis)
• The applicable part of Lemon balm is the leaf and leaf
oil. Lemon balm seems to have sedative, antioxidant, and
antiviral effects. (7,8,9,10) Lemon balm contains citronellal,
neral, and geranial monoterpenoid aldehydes; flavonoids and
polyphenolic compounds (including rosmarinic acid); and
monoterpene glycosides.
• These substances may contribute to the behavioral effects of
lemon balm dried leaf and essential oil. (8) Some research
suggests lemon balm might have acetylcholine receptor
References
1. Kalant H, Roschlau WHE, Eds. Principles of Med. Pharmacology. New
York, NY: Oxford Univ Press, 1998
2. Bloom FE, Kupfer DJ. Psychopharmacology: The Fourth Generation of
Progress. New York, NY: Raven Press, Ltd., 1995.
3. Kakuda T, Yanase H, Utsunomiya K, et al. Protective effect of gamma-
glutamylethylamide (theanine) on ischemic delayed neuronal death in
gerbils. Neurosci Lett 2000;289:189-92
4. Sadzuka Y, Sugiyama T, Sonobe T. Efficacies of tea components on
doxorubicin induced antitumor activity and reversal of multidrug resistance.
Toxicol Lett 2000;114:155-62.
5. Mason R. 200 mg of Zen; L-theanine boosts alpha waves, promotes alert
relaxation. Alternative & Complementary Therapies 2001,April; 7:91-95
6. Lu K, Gray MA, Oliver C, et al. The acute effects of L-theanine in comparison
with alprazolam on anticipatory anxiety in humans. Hum Psychopharmacol
Clin Exp 2004;19:457–65
7. Wolbling RH, Leonhardt K. Local therapy of herpes simplex with dried
extract from Melissa officinalis. Phytomedicine 1994;1:25-31.
8. Kennedy DO, Scholey AB, Tildesley NT, et al. Modulation of mood and
cognitive performance following acute administration of Melissa officinalis
(lemon balm). Pharmacol Biochem Behav 2002;72:953-64.
9. Akhondzadeh S, Noroozian M, Mohammadi M, et al. Melissa officinalis
extract in the treatment of patients with mild to moderate Alzheimer’s
disease: a double blind, randomised, placebo controlled trial. J Neurol
Neurosurg Psychiatry 2003;74:863-6.
10. Koytchev R, Alken RG, Dundarov S. Balm mint extract (Lo-701) for topical
treatment of recurring herpes labialis. Phytomedicine 1999;6:225-30
11. Hormann HP, Korting HC. Evidence for the efficacy and safety of topical
herbal drugs in dermatology: part I: anti-inflammatory agents. Phytomedicine
1994;1:161-71.
12. Viola H, Wasowski C, Levi de Stein M, et al. Apigenin, a component of
Matricaria recutita flowers, is a central benzodiazepine receptors-ligand with
anxiolytic effects. Planta Med 1995;61:213-6.
13. Avallone R, Zanoli P, Puia G, et al. Pharmacological profile of apigenin,
a flavonoid isolated from Matricaria chamomilla. Biochem Pharmacol
2000;59:1387-94.

Model: NP035
* Manufactured by: Genoma Nutritionals

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