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Name: Age: Sex: Physician: Diagnosis:

DRUG DATA CLASSIFICATION MECHANISM OF INDICATIONS CONTRAINDICATIONS SIDE EFFECTS NURSING RESPONSIBILITIES
ACTION

Generic Name Functional Class Interferes with protein  Pulmonary Contraindicated in CNS: confusion, Before
Streptomycin Antitubercular/ synthesis in bacterial tuberculosis, as an patients with depression, numbness, Assess:
Antiinfective cell by binding to adjunct hypersensitivity, tremors, seizures,  Weight before treatment;
Trade Name ribosomal 30 S,  Streptococcal severe renal disease, muscle twitching, calculation of dosage is usually
Streptomycin Chemical Class causing inaccurate endocarditis Pregnancy D neurotoxicity, dizziness based on ideal body weight
Aminoglycoside peptide sequence to  Enterococcal CV: hypotension,  I & O ratio, U/A daily for
Patient’s Dose form in protein chain, endocacrditis Precautions myocarditis, palpitations proteinuria, cells, casts
Pregnancy Category causing bacterial death Neonates, mild renal EENT: ototoxicity,  Deafness by audiometric testing,
D disease, myasthenia deafness, visual ringing, roaring in ears
gravis, lactation, disturbances, tinnitus  C&S before starting treatment to
Minimum Dose Patient’s Indications hearing deficit, GI: abdominal distress, identify infecting organism
15 mg/kg daily IM x 2-3 Pharmacokinetics geriatric, Parkinson’s anorexia, nausea,  Vestibular dysfunction; nausea,
mos disease, hepatic vomiting, increased vomiting, dizziness, headache
IM, Onset rapid, Peak disease AST, ALT,
Maximum Dose 1-2 hr, plasma half-life hepatomegaly, hepatic During
1 g/kg daily IM x 2-3 2 ½ hr; not Interactions necrosis, Administer:
mos metabolized, excreted  Increase: ototoxicity, sploenomegaly  IM inj in large muscle mass, rotate
unchanged in urine, nerotoxicity, GU: oliguria, hematuria, inj sites
Availability crosses placental neprotoxicity- other renal damage,  Drug in evenly spaced doses to
Tabs 100, 400 mg barrier, poor aminoglycosides, azotemia, renal failure, maintain blood level
penetration into CSF, amphotericin B, nephrotoxicity  Antiemetic if vomiting occurs
small amounts enter cephalosporins, INTEG: dermatitis,  Adequate fluids of 2-3 L/day unless
breast milk mannitol, furosemide pruritus, rash, burning, contraindicated to prevent irritation
 Increase: alopecia of tubules
streptomycin effects- HEMA:
nondepolarizing agranulocytosis, After:
muscle relaxants, thrombocytopenia, Teach/Tell patient/SO to:
succinylcholine, leucopenia,  Serum peak 20-30 min after IM inj,
warfarin, NSAIDs eosinophilia, anemia trough level drawn 8 hr; acceptable
levels- peak 5-25 mcg/ml, trough
Treatment of should not be >5 mcg/ml
Overdose  To report headache, dizziness,
Hemodialysis; monitor renal impairment
serum levels of drug  To report loss of hearing, ringing,
roaring in ears, fullness in head

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