Brand Name: Zithromax

Generic Name: Azithromycin dihydrate

Drug Classification:
Indication: Upper & lower resp tract infections, skin & soft tissue infections, otitis media
Mechanism of Action: The mechanism of action of azithromycin is inhibition of protein synthesis in bacteria by
binding to the 50S ribosomal subunit and preventing translocation of peptides.
Macrolides are protein synthesis inhibitors. The mechanism of action of macrolides is inhibition of bacterial protein
biosynthesis, and they are thought to do this by preventing peptidyltransferase from adding the peptidyl attached
to tRNA to the next amino acid[1] (similarily to chloramphenicol)[citation needed] as well as inhibiting ribosomal
translocation.[1] Another potential mechanism is premature dissociation of the peptidyl-tRNA from the ribosome
Contraindication: Hypersensitivity to macrolides.
Adverse Reaction: Dizziness/vertigo, convulsions (as seen with other macrolides), headache, somnolence,
paresthesia and hyperactivity.
Nursing Responsiblities:
 Monitor for superinfection
 Encourage to increase fluid intake
 Monitor urine output for signs of renal …

Brand Name: Mucosta

Generic Name: Rebamipide
Drug Classification: Antacid
Indication: Peptic ulcer, Gastritis,
Mechanism of Action: Rebamipide is a mucosal protective agent and is postulated to increase gastric blood flow,
prostaglandin biosynthesis and decrease free oxygen radicals.
Contraindication: Lactation
Adverse Reaction: Rash, pruritus, constipation, diarrhoea, nausea.
Nursing Responsiblities:
 Monitor for any adverse reaction

Brand Name: Nexium

Generic Name: Esomeprazole Mg
Drug Classification: Antacid, Proton Pump inhibitor
Indication: Esophagitis, GERD, hypersecretory conditions
Mechanism of Action: Proton pump inhibitors act by irreversibly blocking the hydrogen/potassium adenosine
triphosphatase enzyme system (the H+/K+ ATPase, or, more common, gastric proton pump) of the gastric parietal
cell. The proton pump is the terminal stage in gastric acid secretion, being directly responsible for secreting H + ions
into the gastric lumen, making it an ideal target for inhibiting acid secretion
Contraindication:
Adverse Reaction: Headache, abdominal pain, diarrhea, flatulence, nausea, vomiting, constipation.
Nursing Responsiblities:
Brand Name: Claricort
Generic Name: Loratadine 5 mg, betamethasone 250 mcg.
Drug Classification: Antihistamine
Indication: Relief of symptoms of atopic dermatitis, angioedema, urticaria, seasonal & perennial allergic rhinitis,
food & drug allergic reaction.
Mechanism of Action: By using loratadine-betamethasone in combination, tablets combine the anti-inflammatory
and antiallergic effect of the corticosteroid (betamethasone) with the nonsedating antihistamine (loratadine).
Loratadine is a potent long-acting tricyclic antihistamine with selective peripheral H 1-receptor antagonistic activity.
Glucocorticosteroids eg, betamethasone, cause profound and varied metabolic effects and modify the body's
immune response to diverse stimuli.
Contraindication: Patients with systemic fungal infections, in those with sensitivity reactions to betamethasone or
to other corticosteroids or to any component of Claricort.

Adverse Reaction: Fatigue, headache, somnolence, nervousness, dry mouth, gastrointestinal disorders eg, nausea,
gastritis

] Brand Name: Carnicor

Generic Name: L-carnitine
Drug Classification:
Indication: Acute and chronic myocardial ischemia, angina pectoris, arrhythmia, cardiac failure.
Mechanism of Action: L-Carnitine is a natural constituent of the cells where it performs a fundamental role in the
utilization of lipid substrates. L-Carnitine is in fact the only carrier utilizable by the long-chain fatty acids to cross
the inner mitochondrial membrane, and be directed towards β-oxidation. Carnitine also indirectly influences
glucose and protein metabolism: Oxidation of the acyls reduces the peripheral use of glucose while permitting
entry of the acetyls (residue from β-oxidation) in the Kreb's Cycle, increasing, as a consequence, the cell's available
energy. The therapeutic use of carnitine in myopathies caused by its lack has been a determining factor and has
recently proved especially useful in cardiac pathology. In this regard, it must be remembered that the major
natural reservoirs of carnitine are the skeletal muscles and the myocardium: The latter, even though able to utilize
various substrates for energy, has a preference for free fatty acids. Moreover, carnitine performs an essential role
in cardiac metabolism as oxidation adequate quantities of the substance. Experimental studies have shown that in
various stress conditions, in acute ischemia and diphtheric myocarditis, a lowering of myocardial tissue levels of
carnitine is evident. Many animal models have confirmed positive carnitine activity in various artificially-induced
changes in heart function: Acute and chronic ischemia, decompensation states, heart failure due to diphtheric
myocarditis, cardiotoxicity from drugs (propanolol, adriamycin).
Carnitine has proven clinically effective in acute and chronic heart failure (angina pectoris), myocardial sclerosis, in
states of decompensation and in various rhythm disorders (arrhythmias due to tricyclic antidepressants). An
increase in heart contractility and in tolerance to stress was evidenced especially with regard to chronic ischemia
and angina, without any increase in oxygen consumption by the myocardium.
Contraindication: Patients with known hypersensitivity to L-Carnitine.
Adverse Reaction: L-Carnitine has virtually no side effects. It is a natural metabolite of the body.