Welcome to Scribd, the world's digital library. Read, publish, and share books and documents. See more
Download
Standard view
Full view
of .
Save to My Library
Look up keyword
Like this
8Activity
0 of .
Results for:
No results containing your search query
P. 1
Nasal Topical Therapeutics

Nasal Topical Therapeutics

Ratings: (0)|Views: 2,444|Likes:
This e book takes a look at the new emerging frontier of nasal administration of drugs and vaccines.
This e book takes a look at the new emerging frontier of nasal administration of drugs and vaccines.

More info:

Published by: Dr. T. Balasubramanian on Aug 17, 2010
Copyright:Attribution Non-commercial

Availability:

Read on Scribd mobile: iPhone, iPad and Android.
download as PDF, TXT or read online from Scribd
See more
See less

10/19/2010

pdf

text

original

 
 
qwertyuiopasdfghjklzxcvbnmq
 
wertyuiopasdfghjklzxcvbnmqw
 
ertyuiopasdfghjklzxcvbnmqwer
 
tyuiopasdfghjklzxcvbnmqwerty
 
uiopasdfghjklzxcvbnmqwertyui
 
opasdfghjklzxcvbnmqwertyuiop
 
asdfghjklzxcvbnmqwertyuiopas
 
dfghjklzxcvbnmqwertyuiopasdf 
 
ghjklzxcvbnmqwertyuiopasdfgh
 
jklzxcvbnmqwertyuiopasdfghjkl
 
zxcvbnmqwertyuiopasdfghjklzx
 
cvbnmqwertyuiopasdfghjklzxcv
 
bnmqwertyuiopasdfghjklzxcvbn
 
mqwertyuiopasdfghjklzxcvbnm
 
qwertyuiopasdfghjklzxcvbnmq
 
wertyuiopasdfghjklzxcvbnmqw
 
 
Nasal topical therapeutics
A reality
8/17/2010Dr. T. Balasubramanian
 
 1
Nasal topical therapeutics
ByDr. T. BalasubramanianIntroduction:Intranasal drug delivery systems for the management of local and systemicailments have caught up recently. Initially this route of drug administrationwas attempted for the management of allergic rhinosinusitis. Nowinflammatory sinusitis is also managed by intranasally administered drugs. Thereasons for interest in this route of drug administration because of its highvascularity, porous endothelial basement membrane and a high total bloodflow per volume of tissue.Since first pass metabolism is avoided in this drug delivery method the drugis metabolized slowly thus helping in reducing the dosage of the drug. Thisalso goes a long way in reducing the potential toxicity of the administered drugeven if it has a very low therapeutic index.The complex nasal anatomy and the varying dynamics of nasal air flow makethis drug delivery modality a little bit unpredictable. This is more so especiallyin patients with nasal cold which is associated with congestion of nasal mucosaand turbinates.
 
 2
Variables that have a significant bearing on intranasal drug absorption:1.
 
Particle size of the drug2.
 
Flow volume3.
 
Pressure4.
 
Spray angle5.
 
Complex anatomy6.
 
Nasal airflow dynamicsRole of particle size of the drug:Primary nasal drug delivery system works on the inertial impaction while thedrug is deposited and secondarily gravitational sedimentation and Brownian

Activity (8)

You've already reviewed this. Edit your review.
1 thousand reads
1 hundred reads
Aatif_Saif_80 liked this
dheerajsood liked this
Peng Xiang liked this
Sam Kam liked this

You're Reading a Free Preview

Download
/*********** DO NOT ALTER ANYTHING BELOW THIS LINE ! ************/ var s_code=s.t();if(s_code)document.write(s_code)//-->