Welcome to Scribd. Sign in or start your free trial to enjoy unlimited e-books, audiobooks & documents.Find out more
Download
Standard view
Full view
of .
Look up keyword or section
Like this
12Activity

Table Of Contents

2.4.Thermodynamic Activity
2.8.The Cut-off Point
(a) Taft’s Steric Factor (Es),
2.9.1.Taft’s Steric Factor (Es)
2.10.Hansch Equation
2.11.The Craig Plot
2.12.The Topliss Scheme
3.FACTORS GOVERNING ABILITY OF DRUGS TO REACH ACTIVE SITE
3.2.Distribution
3.3.Metabolism (Biotransformation)
3.5.Intramolecular Distances and Biological Activity
4.DISSOCIATION CONSTANTS
4.1.Drugs Exerting Action as Undissociated Molecules
4.2.Drugs Exerting Action as Ionized Molecules
5.ISOSTERISM AND BIO-ISOSTERISM
5.1.Classical Bioisosteres
2.1.Molecular Mechanics
3.KNOWN RECEPTOR SITES
3.1.3D Structure of Macromolecular Targets
3.3.Major Steps in Structure-Based Drug Design
3.4.Ligand Receptor Recognition
3.5.Active Site for a Target Molecule
3.7.Characterization of Site
3.7.1. Hydrogen Bonding and Other Group Binding Sites
3.8.Design of Ligands
(a) Visually assisted design,
3.8.1. Visually Assisted Design
3.8.2. 3D Databases
3.8.3. ‘Divide-and Rule’ Concept in Design of Ligands
3.8.4. De Novo Design
3.9.Calculation of Affinity
3.9.1. Components of Bonding Affinity
3.9.2. Binding Energetics and Comparisons
3.9.4. Multiple Binding Modes
4.UNKNOWN RECEPTOR SITES
unknown receptor sites :
(a) Pharmacophore Vs binding-site models,
4.1.Pharmacophore Vs Binding-site Models
4.1.1. Pharmacophore Models
4.1.2. Binding-Site Models
4.1.3. Molecular Extensions
4.1.4. Activity Vs Affinity
4.2.Searching for Similarity
4.2.1. Simple Comparisons
4.3.Molecular Comparisons
5.PREDICTIVE ADME*
6.REVERSE DESIGNING
6.1.High Throughput Screening
6.2.Combinatorial Chemistry
2.1.Inhalation Anaesthetics
2.3.Basal Anaesthetics
3.MODE OF ACTION OF GENERAL ANAESTHETICS
3.1.Lipid Theory
3.2.Physical Theory
3.3.Biochemical Theory
3.5.Meyer-Overton Theory
4.MECHANISM OF ACTION OF GENERAL ANAESTHETICS
2.2.Piperidine or Tropane Derivatives
2.5.Miscellaneous Type
3.CHEMICAL CONSIDERATIONS OF LOCAL ANAESTHETIC DRUG SUBSTANCES
3.1.1.Lipophilic Entity
3.1.3.Hydrophilic Entity
5.MODE OF ACTION OF SOME SELECTED LOCAL ANAESTHETICS
2. CLASSIFICATION
3.MODE OF ACTION OF BARBITURATES
4.MECHANISM OF ACTION
5.BARBITURATES Vs BENZODIAZEPINES
6.STRUCTURE-ACTIVITY RELATIONSHIP
7.BARBITURATES Vs DISSOCIATION CONSTANT (pKa)
8.SUBSTITUTIONS ON HETERO ATOMS IN BARBITURATES
CATALYZED DEGRADATION OF BARBITURATES
10.SPECIFIC MECHANISM OF ACTION OF SOME SEDATIVES AND HYPNOTICS
2.2Hydantoin Derivatives
2.3.Oxazolidinediones
2.4.Succinimides
3.CHEMOTHERAPY* OF EPILEPSY
4.MECHANISMS OF ACTION FOR THE ANTICONVULSANTS
5.SPECIFIC MECHANISMS OF SELECTED ANTICONVULSANTS
2.1Neuromuscular Blocking Drugs
2.2Centrally Acting Muscle Relaxants
3. GENERAL MECHANISM OF ACTION OF MUSCLE RELAXANTS
2.1.Xanthine Derivatives
3.CNS-PEPTIDES, S-GLUTAMATE AND BLOCKADE OF NMDA-INDUCED RESPONSES
3.1.CNS-Peptides
3.2.S-Glutamate and Blockade of NMDA-Induced Responses
4.MECHANISM OF ACTION OF SELECTED CNS-STIMULANTS
2.1.Aniline and p-Aminophenol Analogues
2.2.Salicylic Acid Analogues
2.3.Quinoline Derivatives
2.4.Pyrazolones and Pyrazolodiones
3.MECHANISM OF ACTION
4.MECHANISM OF ACTION OF SELECTED ANTIPYRETIC-ANALGESICS
2.LIMITATIONS OF OPIATE ANALGESICS
3.CHARACTERISTIC FEATURES OF OPIOIDS
(i) Opioid peptides,
3.1.Opioid Peptides
3.2.Opioid Receptors
3.3.Orphan Opioid Receptor
3.4.Mu Opioid Receptors
3.5.Kappa Opioid Receptors
3.6.Delta Opioid Receptors
4.CLASSIFICATION
4.1.Morphine Analogues
4.2.Morphinan Analogues
4.3.Morphan Analogues
4.4.4-Phenylpiperidine Analogues
4.5.Phenylpropylamine Analogues
4.6.Miscellaneous Analogues
5.NARCOTIC ANTAGONISTS
6.MORPHINE : STRUCTURAL REPRESENTATIONS
7.MECHANISM OF ACTION OF CERTAIN NARCOTIC ANALGESICS
3. CARDIAC GLYCOSIDES
3.1.Designing the Cardiac Glycoside Receptor
3.2.Mechanism of Action
4. ANTIHYPERTENSIVE AND HYPOTENSIVE DRUGS
(a) Renin-angiotensin pathway,
(b) Angiotensin II receptor antagonists and
4.3.Potential-Dependent Calcium Channels
5. ANTIARRHYTHMIC AGENTS
5.1.Membrane-Stabilizing Agents
5.2.Antisympathetic Drugs
5.2.1.Mechanism of Action
5.3.Prolonging Cardiac Action
5.3.1Mechanism of Action
5.4.1.Mechanism of Action
6.VASOPRESSOR DRUGS
6.1. Mechanism of Action
3. SYMPATHOMIMETIC DRUGS
3.1.Mechanism of Action
4.BETA ADRENERGIC RECEPTOR STIMULANTS
4.1.Mechanism of Action
5.1.1.Mechanism of Action
5.2.1.First Generation βββββ-Blockers
5.3.Alpha- and Beta-Adrenergic Receptor Blocking Agent
6. CHOLINOMIMETIC (PARASYMPATHOMIMETIC) DRUGS
(a) Directly Acting
6.1.Directly Acting
6.2.Indirectly Acting (Anticholinesterase) Drugs
6.2.1.Mechanism of Action
7. ANTIMUSCARINIC (ANTICHOLINERGIC) AGENTS
7.1.Aminoalcohol Esters
7.2.Aminoalcohol Ethers
7.7.Miscellaneous Amines
7.8.Mechanism of Action
8.GANGLIONIC BLOCKING AGENTS
8.1.Mechanism of Action
9.ADRENERGIC NEURONE BLOCKING AGENTS
9.1.Mechanism of Action
(a) Mercurial Diuretics,
2.1.Mercurial Diuretics
2.2.Non-Mercurial Diuretics
2.2.2. Carbonic Anhydrase Inhibitors
2.2.3.Miscellaneous Sulphonamide Diuretics
2.2.4. ‘Loop’ and ‘High-Ceiling’ Diuretics
2.2.5.Aldosterone Inhibitors
2.2.8.Osmotic Diuretics
2.2.9.Acidotic Diuretics
2.2.10.Miscellaneous Diuretics
2.1.1.Aminoalkylethers
2.1.2. Ethylenediamines
2.1.3. Thiophene Derivatives
Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)
2.1.1. Mechanism of Action
2.3.1. Mechanism of Action
2.4.Naphthalene Acetic Acid Analogues
2.4.1. Mechanism of Action
2.5.1. Mechanism of Action
2.6.Miscellaneous Anti-Inflammatory Drugs
2.6.1. Antimalarial Agents
2.6.2. Uricosuric Agents
2.7Salicylic Acid Analogues
2.1. Piperidine Analogues
2.2Pyrrolidine Analogue
2.2.1. Mechanism of Action
2.3Phenothiazine Analogue
2.4Miscellaneous Drugs
2.1. Sedative Expectorants
2.2Stimulant (Irritant) Expectorants
2.3 Centrally Acting Antitussive Agents
2.2.1. Mechansim of Action
2.3. Sulphonamides for Intestinal Infections
3.IONIZATION OF SULPHONAMIDES
5.CHEMOTHERAPEUTIC CONSIDERATION
2.1. 4-Aminoquinoline Analogues
2.3.9-Aminoacridines
2.7.Quinine Analogues
2.1.Piperazines
2.2.Benzimidazoles
2.4. Antimalarials
2.5. Natural Products
2.INSULIN-PRIMARY STRUCTURE
3.ORAL HYPOGLYCEMIC AGENTS
(a) First-generation sulfonylureas, and
3.1.2.Second-Generation Sulfonylureas
3.2. Non-Sulfonylureas-Metaglinides
3.4.Bisguanides
3.5. ααααα-Glucosidase Inhibitors
2. STEROID NOMENCLATURE, NUMBERING, DOUBLE BONDS AND STEREOCHEMISTRY
3. CLASSIFICATION
3.2.Sex Hormones
3.2.1.Classification
3.3. Cardiac Glycosides
(a) Short-to medium acting glucocorticoids,
2.1. Short-to Medium Acting Glucocorticoids
2.2. Intermediate Acting Glucocorticoids
2.3.Long Acting Glucocorticoids
2.4.Mineralocorticoids
1. INTRODUCTION
(a) β-Lactam antibiotics,
3. βββββ-LACTAM ANTIBIOTICS
3.1. Penicillins
3.2. Cephalosporins
4. AMINOGLYCOSIDE ANTIBIOTICS
5. CHLORAMPHENICOL
6.1. Salient Features of the Tetracyclines
6.2. Nomenclature
6.4. Structure Activity Relationship (SAR)
6.5. Newer Tetracyclines
2 CLASSIFICATION
2.1. First-Line Drugs
2.2. Second-Line Drugs
1.1.1. Phase Specificity
1.1.5. Combination Chemotherapy
1.1.6. Log Cell-Kill Principle
1.1.7. Drug Resistance
2.1. Alkylating Agents
2.1.1. Mustards
2.1.2. Methanesulphonates
2.1.3. Ethylenimines
2.1.4. Nitrosoureas
2.2. Antimetabolites
2.2.4. Amino Acid Antagonists
2.3. Antibiotics
2.4. Plant Products
2.4.2. Tertiary Amines
2.4.3. Heterocyclic Amines
2.4.4. Lactones
2.4.5. Glycosides
2.5. Miscellaneous Compounds
2.6. Hormones
2.6.1. Mechanism of Action
2.7. Immunotherapy
2.7.1. Mechanism of Action
2.1. Reserpine and Related Alkaloids
2.1.1. Mechanism of Reaction
2.2. Alkylene Diols
2.4. Phenothiazine Compounds
2.4.1. Mecha]nism of Action
2.5. Dibenzazepines
2.5.1. Mechansim of Action
2.1.1.Mechanism of Action
2.3. Substances That Affect Translation on Cell Ribosomes
(i) Prostaglandins and other Eicosanoids
2.1.Proistaglandins and other Eicosanoids
2.3.Hormone Antagonists
2.6.Cardiac Steroids and Related Inotropic Drugs
2.6.1. Cardiac Steroids
2.8.Radiosensitizer
2.8.2. Imaging Radioisotopes
2.10.Drugs to Combat AIDS
Index
0 of .
Results for:
No results containing your search query
P. 1
7498887 Medicinal Chemistry

7498887 Medicinal Chemistry

Ratings: (0)|Views: 31|Likes:
Published by hccs2000

More info:

Published by: hccs2000 on Aug 19, 2010
Copyright:Attribution Non-commercial

Availability:

Read on Scribd mobile: iPhone, iPad and Android.
download as PDF, TXT or read online from Scribd
See more
See less

01/28/2013

pdf

text

original

You're Reading a Free Preview
Pages 20 to 73 are not shown in this preview.
You're Reading a Free Preview
Pages 93 to 272 are not shown in this preview.
You're Reading a Free Preview
Pages 292 to 521 are not shown in this preview.
You're Reading a Free Preview
Pages 541 to 720 are not shown in this preview.
You're Reading a Free Preview
Pages 740 to 960 are not shown in this preview.

Activity (12)

You've already reviewed this. Edit your review.
1 thousand reads
1 hundred reads
reddyarjun19 liked this
reddyarjun19 liked this
reddyarjun19 liked this
knilesh liked this
JamesLai liked this
dantodorov liked this
Mentaldisorder liked this
dustinfranklin liked this

You're Reading a Free Preview

Download