Neeta Rajesh Bhide, (M.Sc.N., M.A. Psyco., M.C.F.H., M.D.F.M. Page 2
Focal involves upper extremity flexor muscle group.
Multifocal asynchronous twitching of several parts of the body.
Generalized bilateral jerks of upper and lower limbs.
Causes of neonatal seizures
Hypoglycemia, Hypocalcaemia, Hyponatremia, Hypomagnesaemia, PyridoxineDeficiency
Developmental neurological problems
Congenital hydrocephalus, microcephaly, cerebral dysgenesis, porencephaly,,Polymicrogyria, hydraencephaly, lissencephaly, Agenesis of corpus callosum
Uremia, Bilirubin encephalopathy
Toxoplasmosis, syphilis, cytomegalovirus, herpes simplex, hepatitis
Bacterial meningitis, viral meningoencephalitis, sepsis, brain abscess
Trauma at birth
Hypoxic brain injury, intracranial hemorrhage, subarachnoid hemorrhage, subduralhemorrhage, intraventricular hemorrhage
Neonates born to narcotic withdrawal or abstinence syndrome: the babies born tothe mother addicted to heroin alcohol, diamorphine, methadone. May manifest withcharacteristic withdrawal symptoms like irritability, high pitched cry, tremors,hyper tonicity, vomiting diarrhea after 48 hours of birth.b.
Local anesthetics: During paracervical block inadvertent injection of localanesthetics into fetal scalp may result in intractable convulsion.c.
Pyridoxine dependency : prolonged maternal administration of vitamin B6duringpregnancy may predispose to this condition.
Benign seizures in neonates
Benign neonatal sleep myoclonus
: It has onset during first week of life and occur assynchronous myoclonic jerks during REM sleep. There are no seizures when the baby isawake. EEG is normal and seizures spontaneously disappear by 2 motnhs of age.2.
Benign familial neonatal convulsions
occur as self limiting isolated clonic seizures onsecond and third day of life the recovery is within 1-6 months of life.3.
Benign idiopathic “ fifth day seizures”
: the multi focal clonic seizures occur on day 5 andusually disssapear on day 15 the cause is umknown though CSF zinc level is reported insome cases.