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Allyl Alcohol Interim Dec 2008 v1

Allyl Alcohol Interim Dec 2008 v1

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Published by rrivera7396
Allyl alcohol: persistence, fate, human exposure, toxicity.
Allyl alcohol: persistence, fate, human exposure, toxicity.

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categoriesTypes, Research, Science
Published by: rrivera7396 on Sep 06, 2010
Copyright:Attribution Non-commercial

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10/30/2011

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INTERIM 
 
5: 
 
12/2008 
 i
ALLYL ALCOHOL(CAS Reg. No. 107-18-6)
 
INTERIM ACUTE EXPOSURE GUIDELINE LEVELS(AEGLs)ForNAS/COT Subcommitte for AEGLs
December 2008
 
 
 
INTERIM 
 
5: 
 
12/2008 
 
INTERIM ACUTE EXPOSURE GUIDELINE LEVELS(AEGLs)ALLYL ALCOHOL(CAS Reg. No. 107-18-6)
 
Oak Ridge National Laboratory, Managed and Operated by UT-Battelle, LLC, for the U.S. Department ofEnergy under contract number DE-AC05-00OR22725.
 
 
 
INTERIM 
 
5: 
 
12/2008 
 
PREFACE
 Under the authority of the Federal Advisory Committee Act (FACA) P. L. 92-463of 1972, the National Advisory Committee for Acute Exposure Guideline Levels forHazardous Substances (NAC/AEGL Committee) has been established to identify,review and interpret relevant toxicologic and other scientific data and develop AEGLsfor high priority, acutely toxic chemicals.AEGLs represent threshold exposure limits for the general public and areapplicable to emergency exposure periods ranging from 10 minutes to 8 hours. Threelevels
C
AEGL-1, AEGL-2 and AEGL-3
C
are developed for each of five exposureperiods (10 and 30 minutes, 1 hour, 4 hours, and 8 hours) and are distinguished byvarying degrees of severity of toxic effects. The three AEGLs are defined as follows:AEGL-1 is the airborne concentration (expressed as parts per million ormilligrams per cubic meter [ppm or mg/m
3
]) of a substance above which it is predictedthat the general population, including susceptible individuals, could experience notablediscomfort, irritation, or certain asymptomatic, non-sensory effects. However, theeffects are not disabling and are transient and reversible upon cessation of exposure.AEGL-2 is the airborne concentration (expressed as ppm or mg/m
3
) of asubstance abovewhich it is predicted that the general population, including susceptible individuals, couldexperience irreversible or other serious, long-lasting adverse health effects or animpaired ability to escape.AEGL-3 is the airborne concentration (expressed as ppm or mg/m
3
) of asubstance above which it is predicted that the general population, including susceptibleindividuals, could experience life-threatening health effects or death.Airborne concentrations below the AEGL-1 represent exposure levels that couldproduce mild and progressively increasing but transient and nondisabling odor, taste,and sensory irritation or certain asymptomatic, non-sensory effects. With increasingairborne concentrations above each AEGL, there is a progressive increase in thelikelihood of occurrence and the severity of effects described for each correspondingAEGL. Although the AEGL values represent threshold levels for the general public,including susceptible subpopulations, such as infants, children, the elderly, persons withasthma, and those with other illnesses, it is recognized that individuals, subject tounique or idiosyncratic responses, could experience the effects described atconcentrations below the corresponding AEGL.

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