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Alzforum EH 20100914

Alzforum EH 20100914

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Published by WorldEventsForum

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Categories:Types, Research
Published by: WorldEventsForum on Sep 15, 2010
Copyright:Attribution Non-commercial

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09/16/2010

 
Selective vulnerability in motorSelective vulnerability in motorneuron disordersneuron disorders
Eva Hedlund, PhDEva Hedlund, PhDLudwig Institute for Cancer ResearchLudwig Institute for Cancer ResearchKarolinska Institutet, SwedenKarolinska Institutet, Sweden
 
Selective vulnerability in motor neuron disorders
 Amyotrophic lateral sclerosis (ALS):
Cortical, spinal and lower cranial nerve motor neuronsdegenerate
Somatic motor neurons, but not autonomicmotor neurons
Selective vulnerability among somatic motorneurons:
- Higher cranial nerves damage late or are spared in ALS,SMA and SBMA
The reasons for this selective vulnerabilityare unknown
1. arm muscle2. tongue3. cortical (upper) motor neurons4. brainstem (bulbar) motor neurons5. axon bundles6. rib muscles7. spinal motor neurons8. leg muscle
Spinal bulbar muscular atrophy (SBMA):
Spinal and lower cranial nerve motor neurons are lost
Spinal muscular atrophy (SMA):
Spinal motor neurons degenerate
 
Cell intrinsic and extrinsic disease mechanisms
MuscleMotor neuronAstrocyteMicroglia
Questions:
Why are some motor neurons more vulnerable to degeneration than others?
Can analysis of the normal intrinsic properties of different motor neuron subpopulations giveclues to mechanisms of relative vulnerability?
?ToxicSignal?Activationsignal?
Methodology:
Isolation of individual neurons using laser capture microdissection (LCM) and analysis ofgene expression differences using oligomicroarrays (Rat Genome 230 2.0 Array, Affymetrix)
SchwanncellsInterneuron

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