Differential vulnerability of midbrain DA neurons
Clues for novel neuroprotective strategies
Chee-Yeun Chung, Ph.D.
Senior Research Scientist
Whitehead Institute of Biomedical Research
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Distinct Projection: A9 to the striatum and A10 to limbic andcortical areas
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Independent of etiology, most vulnerable A9 (SN)> A10 (VTA)
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Conserved in animal models of PD(i.e. MPTP, 6-OHDA,
-synucleinopathy)
New approach to Neuroprotection in PD:
Differential Vulnerability of DA neurons
(SN)(VTA)
SNcVTA
Cranialnerve III
A10A9
Human midbrain
The idea is to understand what makes A10 neurons more resistant and apply that knowledge to vulnerable A9 DA neurons, hoping to provide protection!
What could be thebasisof this differential vulnerability?
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Intrinsic factors- innate differences of these neuronse.g.gene expression differences
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Extrinsic factors- surrounding environmente.g. other neurons, glial and microglial cells)
We used laser capture microdissection (LCM) and microarray in the mouse midbrain to address this question.
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