Distinct Projection: A9 to the striatum and A10 to limbic andcortical areas
Independent of etiology, most vulnerable A9 (SN)> A10 (VTA)
Conserved in animal models of PD(i.e. MPTP, 6-OHDA,
New approach to Neuroprotection in PD:
Differential Vulnerability of DA neurons
The idea is to understand what makes A10 neurons more resistant and apply that knowledge to vulnerable A9 DA neurons, hoping to provide protection!