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micro rna

micro rna

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Published by Francis Prathyusha
MicroRNAs: Oncogenes, tumor suppressors or master regulatorsof cancer heterogeneity?
MicroRNAs: Oncogenes, tumor suppressors or master regulatorsof cancer heterogeneity?

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Published by: Francis Prathyusha on Sep 21, 2010
Copyright:Attribution Non-commercial


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MicroRNAs: Oncogenes, tumor suppressors or master regulatorsof cancer heterogeneity?
Presented by:Francis prathyusha
P. MathijsVoorhoeveCancer and Stem Cell Biology Program, Duke-NUS Graduate Medical School, 8 College Road,Singapore 169857, Singaporea r t i c l e i n f o Article history:Received 2 August 2009Received in revised form 2 Sep2009 Accepted 4 September 2009 Available online 10 September 2009
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1. Introduction2. miRNAs as regulators with oncogenic or tumor-suppressive capacities.3. Target prediction: hit and miss .4. The 3UTR and beyond.5. Evaluating miRNA targets in cancer .6. miRNAs confer robustness to biological systems .7. Non-genetic variability contributes to tumor development .8. miRNA expression is impaired in many tumors
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9. Bottlenecks in miRNA biogenesis .10. Auxiliary factors in miRNA biogenesis .11. miRNA expression is reduced in late stage tumors .12. Reduced miRNA expression leads to enhancedtumor aggressiveness.13. Suppressing metastasis: one giant leap or manysmall steps?14. Loss of tumor-suppressive miRNAs may have fringebenefits for tumors .15. Conclusions .References .

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