Professional Documents
Culture Documents
Kuruvilla Pandikattu SJ
Jnana-Deepa Vidyapeeth, Pune
1
“unprecedented choices.”3 Confronted with such dangers and
possibilities, it is irresponsible either to accept this technology
unconditionally or to reject it uncritically.4 Unconditional
acceptance may lead to our own elimination. Uncritical
rejection may make us completely irrelevant. So in this paper
a modest attempt is made to view the chances and dangers
posed by the technological revolution from philosophical
perspectives.
2
Historical Purview
Although the theory of genetics has been known from the time
of Gregor Johann Mendel (1822-1884), the ability to directly
manipulate the genes of plants and animals was developed
during the late 1970’s. When the proposals to begin human
gene manipulation were put forth in the early 1980’s, it
aroused much controversy. A small number of researchers
argued in favour of germline manipulation,5 but the majority
of scientists and others opposed it. In 1983 an important letter
signed by 58 religious leaders said, “Genetic engineering of
the human germline represents a fundamental threat to the
preservation of the human species as we know it, and should
be opposed with the same courage and conviction as we now
oppose the threat of nuclear extinction.”6 In 1985 the U.S.
National Institutes of Health (NIH) approved somatic gene
therapy trials, but said that it would not accept proposals for
germline manipulation “at present.” That ambiguous decision
did little to discourage advocates of germline engineering,
who knew that somatic experiments were the appropriate first
5
Germline manipulations are those made to the genes of the germinal or
reproductive cells (the egg and the sperm). In practice, this means
altering the fertilized egg, the first cell in the embryo to be, so that the
genetic changes will be copied into every cell of the future adult,
including his or her reproductive cells. Normally such changes would be
passed to all future generations, although, as you’ll see when you explore
the site, it is probably possible to avoid that transmission. Germline
technology stands in sharp contrast to the genetic therapy of today which
is somatic. (It treats the soma or the body cells.) For example, genetic
insertions to treat cystic fibrosis are directed at cells in the lining of the
lung mucosa. Somatic interventions don’t reach beyond the patient being
treated, so their potential scope is obviously much more limited than a
germline intervention.
6
Cited in Richard Hayes, “The Quiet Campaign for Genetically
Engineered Humans Earth” Island Journal, Spring 2001, Vol. 16, No. 1
in http://www.genetics-and-
society.org/resources/cgs/2001_earthisland_hayes.html.
3
step in any event. In the period following 1985, and especially
following the first approved clinical attempts at somatic gene
therapy in 1990, advocates of germline engineering began
writing in the medical, ethical, and other journals to build
broader support.
4
germline engineering. Stock declared that the important
question was “not if, but when” germline engineering would
be used. The symposium was attended by nearly 1,000 people
and received front-page coverage in The New York Times, The
Washington Post and elsewhere.
Four months after the UCLA conference one of the key participants,
somatic gene transfer pioneer W. French Anderson, submitted a
draft proposal to the NIH to begin somatic gene transfer
experiments on human foetuses. He acknowledged that this
procedure would have a “relatively high” potential for “inadvertent
gene transfer to the germline.” Anderson’s proposal is widely
acknowledged to be strategically crafted so that approval could be
construed as acceptance of germline modification, at least in some
circumstances. Anderson hoped to receive permission soon to begin
clinical trials.
5
of life on this Earth is our common humanity.” The Human
Genome Project was formally completed in April 2003.9
http://edition.cnn.com/2000/HEALTH/06/26/human.genome.05/
9
For the history of HGP beginning on 1883 see
http://www.ornl.gov/TechResources/Human_Genome/project/timeline.ht
ml. In fact the sequencing took much less time than originally
anticipated.
10
. “Human Genetic Engineering,” an Interview with Richard Hayes
rhayes@socrates.berkeley.edu www.wildduckreview.com, August 2003.
See also Kirk Semple “UN to consider whether to ban human cloning,”
The Asian Age, Mumbai, 4, November 2003, p. 7. The author pleads for
therapeutic cloning which “has considerable potential from a scientific
perspective” and calls for a ban on human cloning.
6
The Ethics of Designing People
Redesigning People
11
The Feb. 27 1997, issue of Nature described a scientific advance that
can only be described as breathtaking -- and alarming. A researcher from
Scotland had managed to grow a healthy adult sheep -- Dolly by name --
from genetic material from a single cell of an adult sheep. On Mar. 4
1997, President Clinton forbade the use of federal funds for human
cloning research. He’s already asked a bioethics advisory commission to
issue recommendations on cloning research. Scottish scientists who
cloned the sheep Dolly indicated that there
were 276 failed cloning attempts before the successful one.
http://whyfiles.org/034clone/main1.html
12
James Watson, President, Cold Spring Harbor Laboratory, quoted in
Engineering the Human Germline: An Exploration of the Science and
Ethics of Altering the Genes We Pass to Our Children, Gregory Stock
and John Campbell, eds. (New York: Oxford University Press, 2000),
pages 79, 85. Watson shared the Nobel prize for Chemistry in 1962 for
the discovery of the structure of DNA, and served as first Director of the
Human Genome Project. See also the criticism of Philip. Sloan entitled
“Determinism, Reductionism and the New Genetics,” in Philip Sloan,
“New Human Genetics and Religious Vision: Some Options for the
Twenty-First Century,” in Job Kozhamthadam, “Contemporary Science
and Religion in Dialogue, ASSR Publications, Pune, 2002, 129-136.
7
The main issue is how far we are willing to go in reshaping
the human body and psyche?13 Science and medicine have
moved from elucidating our genes to manipulating them.
Human gene therapy – science fiction a mere decade ago –
now boasts more than 500 approved human studies and a U.S.
National Institute of Health budget of some $200 million a
year. The ability to make genetic changes to our germinal
cells will represent a major advance in such therapy, because
changes to the first cell of the human embryo are copied into
every cell of the body and can thus reach any tissue. “Genetic
material can be transferred between species, blurring taken-
for-granted integrities and identities. Digital technologies
create new personal and social worlds – new immersive
environments in which concepts of time, space and palce are
reconfigured.”14
13
The Prospects for Human Germline Engineering
Gregory Stock 29.01.1999 found in
http://www.heise.de/tp/english/inhalt/co/2621/1.html.
14
Elaine Graham, “‘Nietzsche Gets a Modem’: Transhumanism and the
Technological Sublime,” Literature & Theology, 16/1 March 2002, 6.
See Job Kozhamthadam, “The Human Genome Project and
Human Destiny,” Omega: Indian Journal of Science and
Religion, 1/1, 36-55.
8
willing to intervene in life’s flow from parent to child. 15
Further, it is claimed: “The right to a custom made child is
merely the natural extension of our current discourse of
reproductive rights. I see no virtue in the role of chance in
conception, and great virtue is expanding choice….If women
are allowed the ‘reproductive right’ or ‘choice’ to choose the
father of their child, with his attendant characteristics, then
they should be allowed the right to choose the characteristics
from a catalog.”16
15
The Prospects for Human Germline Engineering Gregory Stock
29.01.1999
16
James Hughes, “Embracing Change with All Four Arms,” Eubios
Journal of Asian and International Bioethics (Vol. 6, No. 4, June 1996),
pages 94-101, and online at
http://www.changesurfer.com/Hlth/Genetech.html
17
Sally Deneen, “Designer People: The Human Genetic Blueprint Has
Been Drafted, Offering Both Perils and Opportunities for the
Environment. The Big Question: Are We Changing the Nature of
Nature?” http://www.emagazine.com/january-
february_2001/0101feat1.html
9
Such a possibility has been received with mixed feelings. Bill
Joy, the father of Java software and co-founder of Sun
Microsystems, affirms with some feeling of guilt that “our
most powerful 21st-century technologies are threatening to
make humans an endangered species.” In a celebrated article
in Wired Magazine last year, Joy blamed the possible
extinction of humans on a few key causes, including genetic
engineering, robotics and cyborgs.18
Remaking Eden
10
GenRich class...Naturals work as low-paid service providers
or as labourers, and their children go to public schools... If the
accumulation of genetic knowledge and advances in genetic
enhancement technology continue ... the GenRich class and
the Natural class will become ... entirely separate species with
no ability to cross-breed, and with as much romantic interest
in each other as a current human would have for a
chimpanzee.”19 So it is natural that over time, society will
segregate into “GenRich” who control “the economy, the
media, and the knowledge industry,” and the “Naturals,” who
“work as low paid service providers or as laborers.”
Moreover, Silver asserts that these trends should not and
cannot be stopped, because to do so would infringe on
liberty.20
19
David King, “The Threat of Human Genetic Engineering,”
http://www.hgalert.org/topics/hge/threat.htm
20
David King, “The Threat of Human Genetic Engineering,”
http://www.hgalert.org/topics/hge/threat.htm. See also Philip R. Sloan,
“The Biomolecular Revolution: The Challenge of Western BioScience”
in Job Kozhamthadam, Science, Technology and Values: Science-
Religion Dialogue in a Multi-Religious World, ASSR Publications, Pune,
2003, 131-140
21
The most powerful group advocating unfettered use of genetic material
for the dawn of the new species is “Extropians” who are active primarily
in the cyber-world. See www.extropy.com . My personal meetings with
some of them in August 2002 at Oxford has only reinforced this idea.
11
Ethical Challenges22
12
favor of banning certain uses of genetic technology can
evolve, people will have to come to understand that doing so
would not foreclose means of preventing or curing genetic
diseases. 25
Approve
Disapprove
Date Population Conductor Question of
of cloning
cloning
Should
May scientists be
Americans CBS News 11 85
2002 allowed to clone
humans?
May Americans Gallup Do you favor or 8 90
2002 oppose cloning
that is designed
specifically to
result in the
25
Richard Hayes, “The Politics of Genetically Engineered Humans”
Coordinator Exploratory Initiative on the New Human Genetic
Technologies, San Francisco, CA, USA
http://www.organicconsumers.org/Patent/gehumans.cfm.
26
http://www.genetics-and-society.org/analysis/opinion/summary.html.
Though the survey was taken predominantly among the American
population, we may safely extend it to other population too. Details of
the survey could be had from the website. It is unfortunate that the author
could not find comparable survey for the Indian situation.
13
birth of a
human being?
Is it morally
acceptable or
May
Americans Gallup morally wrong 7 90
2002
to clone
humans?
Do you favor or
oppose
Feb / scientific
Mar Americans Pew experimentation 17 77
2002 on the cloning
of human
beings?
Do you think it
is acceptable to
Feb
Americans Fox News use cloning to 7 89
2002
reproduce
humans ?
Nov / Americans Ipsos-Reid Choose a 21 72
14
Dec preferred
2001 policy.
Do you approve
or disapprove of
cloning that is
CNN / USA
Nov designed
Americans Today / 9 88
2001 specifically to
Gallup
result in the
birth of a
human being?
Do you think it
should be legal
Aug or illegal to
Americans ABC News 11 87
2001 clone humans in
the United
States?
15
Regarding
cloning human
July
Americans Zogby beings, are you 8 90
2001
opposed or
supportive?
Should all
Feb
Americans Time / CNN cloning research 7 90
2001
be banned?
Feb Americans Time / CNN Do you think 10 88
2001 scientists should
be allowed to
clone human
16
beings or don’t
you think so?
Are you
opposed to
scientists
March Pricewater- making a
Canadians - 90
2000 houseCoopers genetically
identical copy
of a human
being?
Feb Canadians CTV / Angus I think people 12 87
1998 Reid should have the
17
freedom, in the
future, to clone
themselves and
have a baby
exactly like
themselves to
raise as their
own child.
Human cloning
should never be
allowed and all
research should
be stopped, or
1997 UK Harris 4 72
Cloning should
be allowed
when it
becomes
possible.
In general, do
you think
Dec
Americans Time / CNN cloning is a 14 75
1993
good thing or a
bad thing to do?
18
some of them.27 This criticism is summed up thus: “[G]erm-
line genetic alteration [poses] many risks and potential harms,
without any clear benefit to any individual. It…jeopardizes,
rather than protects, those who are vulnerable….Genetic
enhancement raises the prospect of a society where…people
are treated as things that can be changed according to
someone else’s notions of human perfection.”28
19
have a poor knowledge of genetics, which must be improved
before they will be able to understand the new knowledge.
Incomplete knowledge can be very dangerous when combined
with existing discrimination, as seen with eugenic
programmes earlier this century. We should all realize that we
are genetically different, and normality is very culturally
defined, perhaps as those who can live comfortably, or
anonymously, in a given society? We must be clear that a
pursuit for our lives to be free of physical suffering is not
going to make the ideal world. Genetic defects have a smaller
effect on people than the moral, spiritual defects and lack of
love. Education of social attitude together with science is
required.
Philosophical Issues
researchers who could evaluate the project independently.
31
Steven Sailer is the president of Human Biodiversity Institute .He
illustrated his argument with a colorful slide of a hydrogen bomb
explosion. Cited in In The Pipeline: Genetically Modified Humans?
Richard Hayes
20
Much more than the ethical issues briefly discussed above, I
want to point to some general philosophical issues that emerge
from the human genetic engineering and the possible
emergence of a new (embedded) species.
21
Emergent Nature Chaos vs cosmos
Malleable Nature Natural vs artificial
Nature as Sacred Matter vs Spirit
Nature as Culture Nature vs culture
22
answer the fundamental biological and philosophical question:
What is life?
35
Here we do not need to go deeply into the Kantian characterisation of
humans as “ends in themselves.” See also Job Kozhamthadam “Cloning of
Dolly: Scientific and Ethical Reflections on Cloning,” Vidyajyoti 62
19998). 110-118.
23
The scenario may become frightening. “It’s the materialist-
reductionist-determinist worldview run amok. It’s what
happens when people become disconnected from themselves,
others, and nature.”36
36
. “Human Genetic Engineering,” an Interview with Richard Hayes
rhayes@socrates.berkeley.edu www.wildduckreview.com. The same
ideas are expressed in Kuruvilla Pandikattu, Let Life Be! Jnanam. Pune,
2001.
37
Gina Kolata, “Who Owns Your Genes?” New York Times May 15,
2000 A SPECIAL REPORT .
38
Sidney A. Diamond, “Commissioner of Patents and Trademarks, petitioner, V.
Ananda M. Chakrabarty etal.” 65L ed 2d 144, 16 June 1980, 144-47.
39
U.S. Patent and Trademark Office,
Animals-P atentability(Washington, D.C.:
U.S. Patent and Trademark Office, 7 April 1987), cited in Kimbrell, 199. Andrew
Kimbrell,The Human Body Shop: The Engineering and Marketing of(San Life
Francisco: HarperSan Francisco, 1993), 233-34.
24
PTO’s 1987 ruling, embryos and fetuses, human life forms not
presently covered under Thirteenth Amendment protection,
are patentable, as are genetically engineered human tissues,
cells, and genes.”40 Corporate America won the right to own,
use, and sell all multicellular creatures, including human
ones.41 Here is a concrete example: Michael Rose at UC Irvine
has patented human genes that some scientists suspect might
be able to increase our life spans up to 150 years.42
25
competing biotech firms competed with the government-led
consortium to decode vast quantities of human DNA. 44
26
the same time, it is hard to believe that something that can be
done easily and cheaply by people all over the world, and that
furthermore is desired by many people with significant
resources will not be done. In the not-too-distant future,
germline engineering is likely to be in just this position: the
technology will be feasible in hundreds of laboratories
throughout the world and there will be genetic interventions
that many people find alluring.46 But there is also the danger
that the technology may get out of control opening to the
possibility of the total elimination of humanity?
27
most powerful 21st-century technologies – robotics, genetic
engineering, and nanotechnology – are threatening to make
humans an endangered species.”49 We should consider
seriously the statement of the theologians: “Genetic
engineering of the human germline represents a fundamental
threat to the preservation of the human species as we know it,
and should be opposed with the same courage and conviction
as we now oppose the threat of nuclear extinction.”50
49
Bill Joy, “Why the Future Doesn’t Need Us,”
http://www.wired.com/wired/archive/8.04/joy_pr.html
50
“Theological Letter Concerning the Moral Arguments,” presented to the
US Congress by the Foundation on Economic Trends (June 8, 1983)
From http://www.genetics-and-
society.org/overview/quotes/opponents.html
51
Sally Deneen, “Designer People The Human Genetic Blueprint Has
Been Drafted, Offering Both Perils and Opportunities for the
Environment. The Big Question: Are We Changing the Nature of
Nature?” http://www.emagazine.com/january-
february_2001/0101feat1.html
28
monstrous minds and values without science can lead to
mindless monsters.”52
52
Job Kozhamthadam, “The Human Genome Project and Human
Destiny,” Omega: Indian Journal of Science and Religion, 1/1, 55.
29
Appendix
Approve
Disapprove
Date Population Conductor Question of
of cloning
cloning
Do you favour
or oppose
cloning of
May
Americans Gallup human 34 61
2002
embryos for
use in medical
research?
Do you think
it is wrong to
April Stop Human create human
Americans - 59
2002 Cloning embryos for
medical
research?
April Americans Coalition for Favour the 68 26
2002 the government
Advancement allowing
of Medical scientists to
Research do therapeutic
cloning
research to
53
http://www.genetics-and-
society.org/analysis/opinion/summary.html
30
produce stem
cells for
treating life-
threatening
diseases
Do you agree
April Americans to
Americans with Bush’s 29 63
2002 Ban Cloning
position?
April Americans to Agree with
Americans 26 59
2002 Ban Cloning person 1 vs. 2.
Nov Choose a
/ Dec Americans Ipsos-Reid preferred 60 33
2001 policy.
Nov Americans CNN / USA Do you 54 41
2001 Today / approve or
Gallup disapprove of
cloning that is
not designed
specifically to
result in the
birth of a
human being,
but is
designed to
aid medical
research that
might find
treatments for
certain
31
diseases?
Do you think
human
cloning for
medical
Aug
Americans ABC News treatments 33 63
2001
should be
legal or illegal
in the United
States?
Should all
July cloning
Americans Zogby - 40
2001 research be
banned?
Do you
support or
Aug oppose
UK Novartis 28 60
1999 cloning and
growing
human cells?
Feb Canadians CTV / Angus I think that 46 53
1998 Reid cloning
human beings
for such
things as
replacement
body parts,
transplants
and
32
experimenting
with new
drugs, if
carefully
regulated, is
not a bad
thing.
Approve Disapprove
Date Population Conductor Question
of IGM of IGM
Does creating
genetically
superior
human beings
Feb
Americans Time / CNN justify 6 92
2001
creating a
human clone
or don’t you
think so?
Fall Scots System Three Are opposed – ~90
2000 to the creation
of “designer
babies” for
any reason
54
http://www.genetics-and-
society.org/analysis/opinion/summary.html
33
other than to
stop
hereditary
illnesses.
are prepared
to accept
Fall “born-to-
Scots System Three 42 -
2000 order” babies
for medical
reasons
Find genetic
engineering to
change the
March Pricewater- eye colour or
Canadians - 74
2000 houseCoopers other physical
features of an
unborn child
unacceptable.
Find it
acceptable for
scientists to
use
biotechnology
March Pricewater- to cure an
Canadians > 50 -
2000 houseCoopers inherited
medical
condition or
to decrease
the risk of
illness.
1996 Americans NCGR How do you 72 -
feel about
34
scientists
changing the
makeup of
human cells to
prevent/stop
children from
inheriting a
usually
nonfatal
disease?
How do you
feel about
scientists
changing the
makeup of
1996 Americans NCGR human cells to 35 -
improve the
physical
characteristics
children
would inherit?
1994 Japanese Macer How do you 62 -
feel about
scientists
changing the
makeup of
human cells to
prevent/stop
children from
inheriting a
usually
nonfatal
35
disease?
How do you
feel about
scientists
changing the
makeup of
1994 Japanese Macer human cells to 28 -
improve the
physical
characteristics
children
would inherit?
How do you
feel about
scientists
changing the
makeup of
human cells to
1994 Australians Macer 79 -
prevent/stop
children from
inheriting a
usually
nonfatal
disease?
1994 Australians Macer How do you 28 -
feel about
scientists
changing the
makeup of
human cells to
improve the
physical
36
characteristics
children
would inherit?
Do you
approve or
disapprove of
the use of
genetic
engineering to
make it
Dec possible for
Americans Time / CNN 8 88
1993 nations to
produce large
numbers of
individuals
with
genetically
desirable
traits?
How do you
feel about
scientists
changing the
makeup of
March of human cells to
1992 Americans 66 32
Dimes prevent/stop
children from
inheriting a
usually
nonfatal
disease?
1992 Americans March of How do you 43 54
37
feel about
scientists
changing the
makeup of
human cells to
Dimes
improve the
physical
characteristics
children
would inherit?
How do you
feel about
scientists
changing the
makeup of
1987 Americans OTA human cells to 44 -
improve the
physical
characteristics
children
would inherit?
38