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NUCLEIC ACIDS

NUCLEIC ACIDS

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Published by Ram Nivas Ahirwar

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Published by: Ram Nivas Ahirwar on Jul 08, 2008
Copyright:Attribution Non-commercial

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06/15/2010

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NUCLEIC ACIDSNUCLEIC ACIDS
 JULIUS P. MARIO, RMT, JULIUS P. MARIO, RMT,MSMS
 
 many features in common, the primary featuremany features in common, the primary featurethat sets them apart is theirthat sets them apart is their
specificity forspecificity fordifferent amino acidsdifferent amino acids
and theand the
corresponding specific differences of corresponding specific differences of their anticodonstheir anticodons
..EachEach
tRNAtRNA
is anis an
L-shapedL-shaped
,,
single chainsingle chaincomposed of up to 93 ribonucleotidescomposed of up to 93 ribonucleotides
..EachEach
contains up to 15 methylated basescontains up to 15 methylated bases
 and aboutand about
half of the nucleotides arehalf of the nucleotides arebase-paired into double helicesbase-paired into double helices
.. The The
5’ end is often guanosine and is5’ end is often guanosine and isalways phosphorylatedalways phosphorylated
. The. The
3’ end is3’ end isCCACCA
..
Activated amino acids attach to theActivated amino acids attach to theterminal 3-hdroxl rou of theterminal 3-hdroxl rou of the
 
Before DNA replication can actually begin,Before DNA replication can actually begin,
unwindingunwindingprotein must open segments along the DNAprotein must open segments along the DNAdouble helixdouble helix
..
DNA-directed RNA polymerase (primase)DNA-directed RNA polymerase (primase)
catalyzescatalyzesthethe
synthesis of a complementary RNA primersynthesis of a complementary RNA primerof approximately 50 to 100 bases on each DNAof approximately 50 to 100 bases on each DNAstrandstrand
.. Then Then
DNA directed DNA polymerase IIIDNA directed DNA polymerase III
 
addsaddsdeoxyribonucleotides to the 3’ end of thedeoxyribonucleotides to the 3’ end of theprimer RNAprimer RNA
, replicating a segment of DNA, the, replicating a segment of DNA, theOkazaki fragment.Okazaki fragment.
DNA polymerase IDNA polymerase I
thenthen
removes the primer RNAremoves the primer RNAand adds deoxyribonucleotides to fill the gapsand adds deoxyribonucleotides to fill the gapsbetween adjacent Okazaki fragmentsbetween adjacent Okazaki fragments
. The. The
fragments are finally joined togetherfragments are finally joined together
byby
DNADNA

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