There is insufficient information describing the immunological properties of thefungus Fusarium in livestock in different parts of the globe. This fungus ad beenassociated with Deg Nala disease. This affects largely buffalo's and cattle inIndia, Pakistan and Nepal.The precise mechanisms underlying the observedsymptoms of Deg Nala disease is not known. In this study, investigative effortshad been focused on the ability to produce immune response and efficiency ofdiethylamine acetarsol as effective therapeutic agent.
Statement of the Problem
Raising buffaloes and cattle in Pakistan, Nepal and India is one way ofaugmenting the financial resources of village people.These animals are mainlyraised on rice and wheat straw which are of poor nutritional quality .Rice andwheat plant when infested by fungus Fusarium causes severe health problemmany researcher in this regard has documented. Infections that may bedebilitating in nature can cause significant economic losses as a resultofDecreased production confounded by reduced growth rate, mortality andpoor animal performance. An effort to improve animal production in the villagecalls for suitable control or therapeutic measures of any disease. Experimentalevaluation of the immunologic properties and treatment of F. graminearuminfections should be considered.
Objectives of the Study
The general objective of this study was to determine the immunologicalcharacteristics ofF. graminearium infection.The specific objectives were the following:1. To evaluate immunologic responses of experimental animals.
Time and Place of the Study
The study was conducted from October 2002 to January 2003 at the VeterinaryMicrobiology Laboratory, College of Veterinary Science and Medicine, CentralLuzon State University, Science City of Munoz, Nueva Ecija, Philippines.
Review of Literature.
Deg Nala disease is a common infection among buffaloes and cattle in Pakistan,India and Nepal. This has a seasonal occurrence which usually comes during themonths of November to January. It is believed that animals contract the diseasewhen they consume feedstuffs like rice straw infected with Fusarium thatproliferated during storage at winter.IL12, IL4, 11,10) in increasing antifungalactivity of effecter cells has been investigated (Rodriguez et al., 1998; andStevens, 1998).The study of Karki (1999) described the oral and potential useof Arsenic sulfate also termed as Deg Nala Liquor in the area at 2% and 5% ratioand found to be effective. IL12, IL4, 11,10) in increasing antifungal activity ofeffecter cells has been investigated (Rodriguez et al., 1998; and Stevens,1998).Deg Nala disease has been known to exist in Western Pakistan for nearlyhalf a century. The disease got its name because cases in buffalo were firstbeen in the Deg Nala (river) area. Shirlaw (1939) reported the occurrence ofthe disease which affected a large number of buffaloes in the various village ofShekhpura and Mudrika, parts of Deg Nala area during the year 1929-1930.Since then, cases of this disease have been observed in other parts of Pakistan.The disease is no longer confined to area around Deg Nala nowadays but is