VOL 330 15 OCTOBER 2010
page 323page 362pages 333 & 349
Why Testing Improves Memory:Mediator Effectiveness Hypothesis
M. A. Pyc and K. A. Rawson
Testing not only evaluates the state ofmemory, but also improves memorymore than restudy.
Mutations in Patients with
A mutation that changes the speciﬁcityof an enzyme in human cancer is also foundin an inherited metabolic disorder.
Crystal Growth Inhibitors for thePrevention of
-Cystine Kidney StonesThrough Molecular Design
J. D. Rimer
Structural mimics for
-cystine may providedrug treatments for certain types of kidneystones.
>> Perspective p. 325
Atomic-Level Characterization of theStructural Dynamics of Proteins
D. E. Shaw
Millisecond-scale simulations capturebiologically relevant structural transitionsduring protein folding.
>> News story p. 308
Particle Acceleration on MegaparsecScales in a Merging Galaxy Cluster
R. J. van Weeren
Observations show that shocks withinthe intracluster medium are capable ofproducing extremely energetic cosmic rays.
Discovery of a Frank-Kasper
Phase inSphere-Forming Block Copolymer Melts
An unusual crystalline arrangement seenin some metal alloys has also been formedwith phase-separating polymers.
>> Perspective p. 333
Room-Temperature Detection of a SingleMolecule’s Absorption by PhotothermalContrast
Single molecules have been detected throughthe heat they release after absorbing light.
: Principal Control KnobGoverning Earth’s Temperature
A. A. Lacis
Carbon dioxide is the atmosphericgreenhouse gas that exerts the mostcontrol on Earth’s climate.
The Structure of Iron in Earth’s Inner Core
Compression experiments indicate that theiron in Earth’s inner core has a hexagonalclose-packed structure.
Intravascular Danger Signals GuideNeutrophils to Sites of Sterile Inﬂammation
In vivo dynamic imaging reveals the underlyingmechanisms of recruitment of neutrophils intoinjured tissue.
Granulosa Cell Ligand NPPC and ItsReceptor NPR2 Maintain Meiotic Arrestin Mouse Oocytes
A peptide from follicle cells contributes totiming of chromosome segregation in meiosis.
Dom34:Hbs1 Promotes SubunitDissociation and Peptidyl-tRNADrop-Off to Initiate No-Go Decay
C. J. Shoemaker
A eukaryotic protein complex helps detectand destroy “aberrant” messenger RNAsstalled on ribosomes.
Selection at Linked Sites Shapes HeritablePhenotypic Variation in
M. V. Rockman
Genome organization affects the distributionof phenotypic variation in nematode wormsmore than mutation and selection.
>> Perspective p. 326
Rapid Construction of EmpiricalRNA Fitness Landscapes
J. N. Pitt and A. R. Ferré-D’Amaré
Mapping between phenotype and genotypecan be resolved by deep sequencing.
>> Perspective p. 330
Temperature as a Universal Resetting Cuefor Mammalian Circadian Oscillators
E. D. Buhr
The master pacemaker in the mammalian brainresists the resetting effect of temperature toprovide a universal entraining signal.
>> Perspective p. 329
Cell Type–Speciﬁc Loss of BDNF SignalingMimics Optogenetic Control of CocaineReward
M. K. Lobo
Selective manipulation of neuron subtypesproduces opposite effects on behavioralresponses to cocaine.
Pathogenesis and Processingof Secreted Effectors by Caspase-3
C. V. Srikanth
A food-poisoning pathogen uses a hostenzyme to activate its virulence factors.
Published by AAAS