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immune system
1 Constituents: Lymphocytes in blood vessels,
lymphatic vessels and somewhere else,
lymphatic tissues and lymphatic organs.
neutralize antigen
3. Natural killer lymphocyte
Type II: Located within the cortex .It is APC with MHC II
molecules which are involved in thymic cell education
.
Type III: Located at the boundary of the cortex and medulla.
Serve as a barrier that isolate cortex and medulla.
A kind of APCs to present Ag.
Blood-thymus barrier
It is the structure between thymocytes and blood , a ph
ysical barrier to protect developing T-lyphocytes from e
xposure to Ag.
Components: lining endotheium of capillary wall and
its basal lamina;
macrophages in the perivascular C.T.;
type I endothelioreticular cells with
their tight junctions.
Blood-thymus barrier
Thymic medulla
It contains lots of epithelioreticular cells and
loosed packed T lymphocytes.
T lymphocytes here are mature ones.
There have another 3 types of epithelioreticular cells
Ag
Secondary nodule: with germinal center (B cells
proliferates here rapidly).
Lymph node
Specialized high endothelial venules (HEVs)
Location: in he paracortex
lymphatic vessels
Bone marrow
lymph node
Medulla
( 1 ) filtering lymph ;
phagocytosis of macrophage;
B cells proliferate and differentiate into
plasma cells and memory B cells.
3. spleen
the structure of the spleen:capsule,red pulp and white pulp
Capsule of the spleen
White pulp
Paracortex in lymph node
4. storage of blood.
spleen
Key points
1.T-lymphocytes get mature in thymus while B-lymphocytes get mature
in the bone marrow.B-lymphocytes can convert to plasma cells whic
h are responsible for producing Ab.
4.The structure and function of spleen:red pulp and white pulp ( malpig
hian body and ).
Thymic cortex
There are 3 types of epithelioreticular cells in thymic cortex.
epithelioreticular cells