Le fibre muscolari: modificazionicon lo sviluppo, invecchiamentoe allenamento
Marsilio Saccavini
UOC Degenza di Medicina RiabilitativaTREVISO
Developmental MHC and slow MHC isoforms
H
uman genome contains at least10 genesfor M
HC
butonly7 so far identified in mature fibres
(more actually expressed?).
Tw
o isoforms predominate during development:
MHCemb& MHCneo
I
n some muscles t
w
o additional slo
w
M
HC
found: a
tonic
and an
alpha cardiac
(M
HCI
ton & M
HC
E
card)
±
MHCIton
present in mature extrafusal extraocular muscles &developing intrafusal fibres ±
MHCcard
found in extrafusal fibres of mature extraocular andmasticary muscles and in intrafusal fibres.
S
pindle-specific M
HC
found in intrafusal fibres (
MHCif
)
D
evelopment (myogenesis)
Mammalian muscles form by the fusion of myoblasts intomyotubes: i) primary myotubes and ii) secondarymyotubes
±PR
I
MARY MYO
TUBES
: appear bet
w
een
8-10
wks
of gestation(i.e. prior motor innervation), contain:
slow MHC, MHCemb,MHCneo
±
SEC
ON
D
ARY MYO
TUBES
: formed around
10-18
wks
of gestation, contain:
fast MHC, MHCemb, MHCneo
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