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Medical Knowledge Com

Medical Knowledge Com

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Published by Aaron Cusimano, MD
Oncology vaccines and clinical trials.
Oncology vaccines and clinical trials.

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Categories:Types, Research
Published by: Aaron Cusimano, MD on Nov 04, 2010
Copyright:Attribution Non-commercial

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11/17/2014

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1MEDICALKNOWLEDGE.COM
ONCOLOGY VACCINES
 
ONCOLOGY STUDIES
It has been more than 100 years since the first reportedattempts to activate a patient's immune system to eradicatedeveloping cancers. Although a few of the subsequent vaccinestudies demonstrated clinically significant treatment effects,active immunotherapy has not yet become an establishedcancer treatment modality. Two recent advances have allowedthe design of more specific cancer vaccine approaches:improved molecular biology techniques and a greater understanding of the mechanisms involved in the activation of Tcells.
 
ONCOLOGY STUDIES
These advances have resulted in improved systemic anti tumor immune responses in animal models. Because most tumor antigens recognized by T cells are still not known, the tumor cell itself is the best source of immunizing antigens. For thisreason, most vaccine approaches currently being tested in theclinics usewhole cancer cellsthat have been geneticallymodified to express genes that are now known to be criticalmediators of immune system activation. In the future, themolecular definition of tumor-specific antigens that arerecognized by activated T cells will allow the development of targeted antigen-specific vaccines for the treatment of patientswith cancer.

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