Neuroscience 9/21/10 DiscussionSynaptic Transmission1.
effect on postsynaptic cell4.
quantum = one vesicle, discreet variableESPS / ISPSReceptors on the post-synaptic membrane -40 -65
igand/NT/Chemically(what binds to the channel) Gated Channel
Ch Na+ Depol EXCIT
TORYGlutamate Na+ Depol EXCIT
Cl- Hyper INHI
ITORYGlycine Cl- Hyper INHI
G-Protein Coupled Receptors1.
hat are they good for?
ore widespread signal, slower, diverse
How do they work?3.
Nonepinephrine(NT) binds to receptor
G-protein activatesadenocyclase(effector/enzyme) which converts
K+channel which closes
Back up, zoom in pg. 159
gamma + beta + alpha(GDP)
drop GDP, picks up GTP, two subunits split in opposite directions, alphawhich has GTP breaks down to GDP which terminates it, and subunits comeback together