Welcome to Scribd. Sign in or start your free trial to enjoy unlimited e-books, audiobooks & documents.Find out more
Download
Standard view
Full view
of .
Look up keyword
Like this
1Activity
0 of .
Results for:
No results containing your search query
P. 1
neuro3

neuro3

Ratings: (0)|Views: 30|Likes:
Published by Mo Hy

More info:

Categories:Types, School Work
Published by: Mo Hy on Nov 09, 2010
Copyright:Attribution Non-commercial

Availability:

Read on Scribd mobile: iPhone, iPad and Android.
download as DOCX, PDF, TXT or read online from Scribd
See more
See less

01/02/2013

pdf

text

original

 
Neuroscience 9/21/10 DiscussionSynaptic Transmission1.
 
synthesis2.
 
release3.
 
effect on postsynaptic cell4.
 
termination
quantum = one vesicle, discreet variableESPS / ISPSReceptors on the post-synaptic membrane -40 -65
NT Receptors
 
L
igand/NT/Chemically(what binds to the channel) Gated Channel
G-Protein
Neurotransmitters
A
Ch Na+ Depol EXCIT
A
TORYGlutamate Na+ Depol EXCIT
A
TORYG
ABA
Cl- Hyper INHI
B
ITORYGlycine Cl- Hyper INHI
B
ITORY
 G-Protein Coupled Receptors1.
 
W
hat are they good for?
M
ore widespread signal, slower, diverse
 2.
 
How do they work?3.
 
Ex. 1
Nonepinephrine(NT) binds to receptor
G-protein activatesadenocyclase(effector/enzyme) which converts
A
TP
*cyclic
A
M
P(secondmsger) activates
protein kinasephosphorylates
K+channel which closes
4.
 
Back up, zoom in pg. 159
G-Protein Complex
gamma + beta + alpha(GDP)
 drop GDP, picks up GTP, two subunits split in opposite directions, alphawhich has GTP breaks down to GDP which terminates it, and subunits comeback together
 
 
 
5.
 
Ex. 2 pg. 162 like Adenocyclase
P
L
C(effector) splits
PIP2 into
*D
A
G stimulate
PKC
*IP3 simulate release of 
*Ca++activates
CamK memory*secondmsgers D
A
G IP3 Ca++ C
A
M
PG-Protein complex either activates ion channel or enzyme.What comes after the ion channel = effector which creates the second msgerTransmitter Gated Vs Voltage  both let in ionsgated  chemical attaches to change conformation, ligand makes it open/closevoltage-gated  has positive/negative
Synaptic Integration
 combination of action potentialsTemporalSpatial
L
ogarithmic decayShunting Inhibition@37%Distance

You're Reading a Free Preview

Download
scribd
/*********** DO NOT ALTER ANYTHING BELOW THIS LINE ! ************/ var s_code=s.t();if(s_code)document.write(s_code)//-->