administration to neonates, infants, or children with physician.PREPARE: Direct: Dilute 2–10 mg in at least 5 mL of sterile water for injection.ADMINISTER: Direct: Give a single dose over 4–5 min. Avoid rapid administration.INCOMPATIBILITIES Solution/additive:
Amphotericin B cholesteryl complex,
Store at 15°–30° C (59°–86° F). Avoid freezing. Refrigerate suppositories. Protectall formulations from light.
Adverse Effects ( 1%)
Body as a Whole: Hypersensitivity [Pruritus, rash, urticaria, edema, hemorrhagic urticaria(rare), anaphylactoid reaction (rare)], sweating, skeletal muscle flaccidity; cold, clammyskin, hypothermia. CNS: Euphoria, insomnia, disorientation, visual disturbances,dysphoria, paradoxic CNS stimulation (restlessness, tremor, delirium, insomnia),convulsions (infants and children); decreased cough reflex, drowsiness, dizziness, deepsleep, coma, continuous intrathecal infusion may cause granulomas leading to paralysis.Special Senses: Miosis. CV: Bradycardia, palpitations, syncope; flushing of face, neck,and upper thorax; orthostatic hypotension, cardiac arrest. GI: Constipation, anorexia, drymouth, biliary colic, nausea, vomiting, elevated transaminase levels. Urogenital: Urinaryretention or urgency, dysuria, oliguria, reduced libido or potency (prolonged use). Other:Prolonged labor and respiratory depression of newborn. Hematologic: Precipitation of porphyria. Respiratory: Severe respiratory depression (as low as 2–4/min) or arrest; pulmonary edema.
Diagnostic Test Interference
False-positive urine glucose determinations may occur using Benedict's solution. Plasmaamylase and lipase determinations may be falsely positive for 24 h after use of morphine;transaminase levels may be elevated.
Drug: cns depressants, sedatives, barbiturates,
benzodiazepines, and tricyclicantidepressants potentiate CNS depressant effects. Use mao inhibitors cautiously; they