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Published by: Project On Government Oversight on Nov 23, 2010
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05/15/2012

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Spring 2003 — Volume 37 • Supplement 1
Psychopharmacology
ULLETI
Advancing the Treatment of Mood
and Anxiety Disorders:
The First 10 Years' Experiencewith Paroxetine
Introduction
By Charles B. Nemeroff MD, PhD
Neuropharmacology of Paroxetine
By Michael j: Owens, PhD, and
Charles B. Nemerof MD, PhD
In Vivo Nenroimaging Correlates of the
Efficacy of Paroxetine in the Treatment
of Mood and Anxiety Disorders
By Clinton Kilts, PhD
Pharnutcokinetics, Drug Interactions, andTolerabllityof Partncetine and Paroxetine CR
By C. Lindsay DeVane, PharmD
Paroxetine Treatment of Major Depressive
Disorder
By Martin B. Keller, MD
Treatment of Panic Disorder:
Focus on Paroxetine
By Mark H. Pollack, MA and Alicia C. Doyle, BA
Paroxetine Treatment of Generalized
Anxiety Disorder
By David V Sheehan, MD, MBA, andC. Gloria Mao, PharmD
Treatment of Posttraumatic Stress Disorder:The Impact of Paroxetine
Byfonathan R. T. Davidson,
MD
Obsessive-Compulsive Disorder:Implications of the Efficacy of an SSRI,
Paroxetine
, By Philip T. 1Vinan, MD
Advances in Recognition and Treatment
of Social Anxiety Disorder:A 10-Year Retrospective
By Murray B. Stein, MD, FRCPC
Paroxetine Use in Medically Ill Patients
By Steven Stout MD, PhD
Wendy I. Somerset, MD,
Andrew Miller, MD, andDominique L Musselman, MD, MS
Paroxetine Treatment of Depression
in Late Life
By Charles F Reynolds HI, MD
Paroxetine Treatment of Mood Disorders in
Women: Premenstrual Dysphoric Disorder
and Hot Flashes
By Kimberly A. Yonkers, MD
Clinical Management of Perinatal
Depression: Focus on Paroxetine
By D. Jeffrey Newport, MA MSG'R, MDkiand Zachary N Stowe, MD
Paroxetine Treatment of Mood and Anxiety
Disorders in Children and Adolescents
By Karen Dineen Wagner; MD, PhD
Efficacy and Tolerability of Controlled-
Release Paroxetine
By Robert N. Golden, MD
I psychopharmbulletin-com
I
 
)N
Key Words: paroxetine, women, premenstrual dysphoric disorder, menopause, breast cancer, hot flashes
Paroxetine Treatment of Mood
Disorders in Women: Premenstrual
Dysphoric Disorder and Hot Flishes
By Kimberly A. Yonkers, MD
ABSTRACT
With the relatively recent introduction of the selective serotonin reuptake
inhibitor (SSRI) class of antidepressants, increased attention has been focused on the use of
antidepressants in the treatment of mood disorders across the female life cycle. Evidence for
the efficacy of antidepressants in the treatment of premenstrual dysphoric disorder
(PMDD) and hot flashes associated with menopause and breast cancer has emerged Theclinical trials experience with paroxetine and the controlled-release (CR) formulation ofparoxetine is reviewed
Psychopharmacology Bulletin.
2003;37(Suppl 1): 135-147
INTRODUCTION
Depression is one of the most significant and disabling illnesses in women-
Findings from the World Health Organization's Global Burden of Disease study
illustrate the relative ranking of depression as a source of death and disability
worldwide and in the United States. Based on 1996 estimates, the leading cause of
disability among both men and women in the United States was ischemic heart
disease. Motor vehicle accidents were the second most common source of deathand disability in men- In sharp contrast, the second largest contributor to disabil-
ity in women was major depression, which in women was ranked higher than
cerebrovascular disease, respiratory tract cancers, osteoarthritis, and breast cancer.'For reasons that are not completely understood, women are at increased risk for
mood disorders compared with men. Gender differences in the rates of majordepression are not apparent in prepubertal children. However, beginning with
puberty and continuing through the end of a woman's childbearing years in midlife,
the ratio of major depression in females to males is 2:12
3
There are particular timesduring a woman's reproductive life, such as pregnancy, the postpartum period, the
Group on Depression in Elderly
dons in depressed nondemcnted
2002;63:396-402.
comparison of nortriptyline and
ne. J
Clin Psychiatry.
1999;60
rh
fluoxetine in geriatric patientsouble-blind studies of paroxetine
1992;53(suppl):57-60.
lulticenter double blind study of
urology.
1995;119:277-281.
entre study of paroxetine versusCsuppl):132-134.le treatment of elderly depressed
vline.
Int Clin Pyschophannacol
acy and safety of paroxetine and
ychiatry.
1998;13:100-108.mmediate-release (IR) formula-
Congress; October 28-31, 2002;
rrence and course of suicidality
a
psychotherapy as maintenance
.n patients older than 59 years.
maintenance pharmacotherarry
-
riptyline in patients older than
.
tyline in the continuation and
13:38-44.ig elderly institution residents:
1998;53:M155-M162.life in geriatric depression: a
rte
Psychiatry.
2001;9:423-428.
Iatient: randomized comparison
harmacat
1994;925-29.
Ids CF 1
-
1. Cognitive effects of
-29.
sertraline and nortriptyline on
-228.parceretine on postural sway in
metine on extrapyramidal signs
tients. Am
J Geriatt Psychiatry.
ing a 1-year trial of fluoxetine.
ressed patients during acute
ndomized trial. Am
J Geriatr
Dr. Yonkers is associate professor of psychiatry at the Yale University School of Medicine in
New Haven, Conn.
To whom correspondence should be addressed: Kimberly A. Yonkers, MD, Yale
University
School of Medicine, 142 Temple St.. Suite 301. New Haven, CT 06510;Tel: 203-764-6621; Fax: 203-
764-6766; E-mall: kimberly.yonkers@yale.edu

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