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Table Of Contents

INTRODUCTION
GENERAL MANAGEMENT OF HEMOPHILIA
What is Hemophilia?
Diagnosis of Hemophilia
Bleeding Manifestations in Hemophilia
Chronic Complications of Hemophilia
Carriers
Comprehensive Care
Comprehensive care team
Functions of comprehensive care program
The family
Management of Hemophilia
Principles of care
Adjunctive management
Home therapy
Prophylaxis
Surgery
Inhibitors
Management of bleeding
Allergic reactions in hemophilia B patients with inhibitors
Immune tolerance induction
Patients switching to new concentrates
Genetic Counselling/Prenatal Diagnosis
Delivery of Infants with Known or Suspected Hemophilia
Vaccination
Psychosocial Issues
Daily living
For the person with hemophilia
For the family
For the community
Dental Care
Monitoring Outcome of Treatment
Sports and Hemophilia
LABORATORY DIAGNOSIS
Introduction
Knowledge and Expertise in Coagulation Laboratory Testing
Principles of diagnosis
Technical aspects
Preparation of the patient prior to taking a blood sample
Collecting the sample
End-point detection
Screening tests
Correction (mixing) studies
Factor assay
Trained personnel
Use of the Correct Equipment and Reagents
Equipment
Reagents
Quality Assurance
External quality assessment scheme (EQAS)
Reference materials and standards
MUSCULOSKELETAL COMPLICATIONS OF HEMOPHILIA
Acute Hemarthrosis
Aspiration
Muscle Hematomas
Chronic Hemarthrosis
Chronic synovitis
Synovectomy
Chronic hemophilic arthropathy
Pseudotumours
Fractures
SELECTION OF CLOTTING FACTOR CONCENTRATES AND OTHER DRUGS
Clotting Factor Concentrates
Choice of products for replacement therapy
Purity
Viral inactivation/elimination
Plasma-derived/recombinant products
Cryoprecipitate
Fresh Frozen Plasma and Cryo-Poor Plasma
Other Pharmacological Options
Desmopressin (DDAVP)
Tranexamic acid
Aminocaproic acid
TREATMENT OF BLEEDING IN HEMOPHILIA
Basic Principles of Treatment
Treatment of Hemophilia A (FVIII Deficiency)
FVIII concentrates
Cryoprecipitate/fresh frozen plasma
Treatment of Hemophilia B (FIX Deficiency)
FIX concentrates
Antifibrinolytic agents
Treatment of Specific Hemorrhages
Joint hemorrhage
Muscle hemorrhage
Iliopsoas hemorrhage
Central nervous system hemorrhage/head trauma
Throat and neck hemorrhage
Acute gastrointestinal (GI) hemorrhage
Acute hemorrhage in the abdomen
Ophthalmic trauma or hemorrhage
Renal hemorrhage
Oral hemorrhage
Epistaxis
Soft tissue hemorrhage
Lacerations and abrasions
Other Management Issues
Dental care
Minor invasive procedures
Allergic reactions to factor replacement products
Plasma Factor Level and Duration of Administration
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Gudelines Mng Hemophilia

Gudelines Mng Hemophilia

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Published by Srinivas Cunduri

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Published by: Srinivas Cunduri on Dec 07, 2010
Copyright:Attribution Non-commercial

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02/10/2013

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