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Glomerulonefrite Acute, Cronice

Glomerulonefrite Acute, Cronice

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Published by ayannapui

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Categories:Types, School Work
Published by: ayannapui on Dec 11, 2010
Copyright:Attribution Non-commercial

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05/23/2013

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GLOMERULONEFRITGLOMERULONEFRITEEACUTE SI CRONICEACUTE SI CRONICEGLOMERULONEFRITGLOMERULONEFRITEEACUTE SI CRONICEACUTE SI CRONICE
 
Leziunea glomerulara poate fi rezultatul unei anomalii-genetice-imunologice-de coagulare
Anomaliile glomerulare genetice
deriva din-mutatii in exonii ADN care codifica unitatiletransciptonale ce vor suferi translatie in ribozomi, responsabili desinteza proteinelor din glomerul, interstitiu, epiteliu tubular;-mutatii ale genelor reglatoare care controleazatranscriptia ADN;-modificari posttranscriptionale anormale aletranscrierii ARN;-modificari posttranslationale anormale ale proteinelor.
Injuria imunologica
e cea mai frecventa cauza a leziuniiglomerulare rezultatul fiind
GLOMERULONEFRITA ²termengeneric ce semnifica inflamatia capilarelor glomerulare.
 
D
EFINITIE
GLOMERULONEFRITA=TERMEN REZERVAT UNEI LARGI VARIETATI
D
E AFECTIUNIGLOMERULARE IN CAREINFLAMATIA GLOMERULARA,MANIFESTATA PRINPROLIFERAREA ELEMENTELORCELULARE ESTE SECUN
D
ARA UNUIMECANISM IMUN.
2 mecanisme majore de agresiune imunologica:-depozite glomerulare de CIC Ag-Ac, care seacumuleaza in MBG ca
depozite granulare
, activeazasistemul Cp si initiaza injuria imuna;-interactiunea Ac cu Ag local in situ (Ag ale MBG)detemina acumularea de
depozite lineare
de Ig si Cp.

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