Was the assignment if patients to treatment Yes,

ramdomised?
Was the randomisation list concealed?
Was follow-up of patients sufficiency long and Yes
complete?
Were all patients analysed in the groups to which Yes
they were ramdomised?
Were patients and clinical kept “blind” to Yes
treatment?
Were the groups treated equality, apart from the
experimental treatment?
Were the groups similar at the start of the trial?

Occurency of Cronic Obstructive Pulmonary Relative Risk Absolute Risk Number

Disease among Amoxycillin and Reduction (RRE) Reduction (ARR) needed to Treat
Amoxycillin/clavulanate (NNT)
Usual Amoxycillin Intensive CER−EER CER-EER 1
Regimen Control Amoxycillin/clavulanat CER ARR
Event (CER) e Regimen
experimental Event
Rate (EER)
9% 4% 55% 5% 3 Patients

± 1,96 (√ CER ×(1−CER)

¿ ofControlPts ) +(
EER ×(1−EER )
¿ ofExperPts )=± 1,96 (
0,9×(1−0,9)
√ 66 )+(
0,4 ×(1−0,4)
69 )=¿ ± 0,93 ¿