First generation cephalosphorins
• Bind to bacterial cell wall membrane, causing cell death.• Active against many gram-positive cocci including: Streptococcuspneumoniae, Group A beta-hemolytic streptococci; Penicillinas-producingstaphylococci.
Skin & skin structure infections; pneumonia; urinary tract infections; bone & joint infections
•Hypersensitivity to cephalosphorins. Serious hypersensitivity to penicillin.
Use Cautiously in:
• Renal impair- ment• History of GI disease, especially colitis• Geriatric patients (consider age-related decrease in body mass,renal/hepatic/ cardiac function, concurrent medications and chronic diseasestates)• Pregnancy or Lactation
SIDE EFFECTS/ ADVERSE EFFECTS
• CNS:Seizures (high doses)• GI:Pseudomembranous colitis, diarrhea, nausea, vomiting, cramps• GU:Interstitial nephritis• DERM:Rashes, urticaria